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Collagen Type IV
Research News and Information
Definition of 'Collagen Type IV'A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. |
Sunday, November 22, 2009
29 Sep 2009 
Proteolysis is essential during branching morphogenesis, but the roles of MT-MMPs and their proteolytic products are not clearly understood. Here, we discover that decreasing MT-MMP activity during submandibular gland branching morphogenesis ... Read more...
Integrin alpha2 mediates selective metastasis to the liver.
6 Sep 2009 Cancers display distinct patterns of organ-specific metastasis. Comparative analysis of a broad array of cell membrane molecules on a liver-metastasizing subline of B16 melanoma versus the parental B16-F0 revealed unique up-regulation of integrin ... Read more...
A sulfilimine bond identified in collagen IV.
2 Sep 2009 Collagen IV networks are ancient proteins of basement membranes that underlie epithelia in metazoa from sponge to human. The networks provide structural integrity to tissues and serve as ligands for integrin cell-surface receptors. They are ... Read more...
Latest indexed articles for 'Collagen Type IV'
These are the very latest articles for this heading:
- Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers.
28 Dec 2009 - MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. 29 Sep 2009
- Integrin alpha2 mediates selective metastasis to the liver. 6 Sep 2009
- A sulfilimine bond identified in collagen IV. 2 Sep 2009
- The role of Tyr71 in Streptomyces trypsin on the recognition mechanism of structural protein substrates. 31 Aug 2009
- Development of decellularized human umbilical arteries as small-diameter vascular grafts. 30 Aug 2009
- Aromatic interactions promote self-association of collagen triple-helical peptides to higher-order structures. 23 Aug 2009
- Alport syndrome. Molecular genetic aspects. 30 Jul 2009
- Pretibial epidermolysis bullosa: is this case a new subtype with loss of types IV and VII collagen? 30 Jul 2009
- Novel human pathological mutations. Gene symbol: COL4A5. Disease: Alport syndrome. 30 Jul 2009
- Prognostic significance of the expression of MUC1 and collagen type IV in advanced gastric carcinoma. 30 Jul 2009
- Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions. 14 Jul 2009
- Effect of adrenotensin on cell proliferation is mediated by angiotensin II in cultured rat mesangial cells. 11 Jul 2009
- Rosiglitazone prevents high glucose-induced vascular endothelial growth factor and collagen IV expression in cultured mesangial cells.
5 Jul 2009 - Glycosaminoglycans restrained in a fibrin matrix improve ECM remodelling by endothelial cells grown for vascular tissue engineering. 29 Jun 2009
- Histological evaluation of mechanical epithelial separation in epithelial laser in situ keratomileusis. 29 Jun 2009
- Effects of multiple chondroitinase ABC applications on tissue engineered articular cartilage. 29 Jun 2009
- Activation of GABA-A receptor ameliorates homocysteine-induced MMP-9 activation by ERK pathway. 29 Jun 2009
- Rosiglitazone alone or in combination with tissue plasminogen activator improves ischemic brain injury in an embolic model in rats. 22 Jun 2009
- Outer membrane protein expression profile in Helicobacter pylori clinical isolates. 20 Jun 2009
See a longer list of these articles.
Technical information about 'Collagen Type IV'
Definition: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
Registry Number: 0
Descriptor UI: D024141
Alternative terms: Collagen Type IV; Type IV Collagen; Collagen, Type IV; Type IV (Basement Membrane) Collagen; Procollagen Type IV; Type IV Procollagen; Procollagen, Type IV; Collagen Type IV, alpha2 Subunit; Collagen Type IV, alpha2 Chain; 7S Collagen; Collagen, 7S; Collagen Type IV, alpha1 Subunit; Collagen alpha1(IV); alpha1(IV) collagen; Collagen Type IV, alpha1 Chain;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.860.300.250.400.100;
History Note: 2002; use COLLAGEN 1990-2001; for PROCOLLAGEN TYPE IV use PROCOLLAGEN 1982-2001; for 7S COLLAGEN use COLLAGEN 1982-2001
Technical Notes: precursors: coord IM with PROCOLLAGEN (IM)