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Collagen Type V - Genetics
Research News and Information
Definition of 'Collagen Type V'A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer. Common names: Collagen Type V; Type V Collagen; Collagen, Type V; Collagen Type V, alpha3 Subunit; Collagen Type V, alpha3 Chain; Collagen alpha3(V); Collagen Type V, alpha2 Subunit; Collagen Type V, alpha2 Chain; Collagen alpha2(V); Procollagen Type V; Type V Procollagen; Procollagen, Type V |
Sunday, November 22, 2009
Molecular mechanisms of classical Ehlers-Danlos syndrome (EDS).
30 May 2009 
Classical Ehlers-Danlos syndrome (EDS) is a heritable disorder characterized by joint hypermobility, skin hyperextensibility, and abnormal wound healing. The majority of affected individuals have alterations in 1 of the 2 type V collagen genes, ... Read more...
29 Apr 2009 BACKGROUND: It has been demonstrated that hypertrophic scar fibroblasts (HSFs) overexpress collagen messenger ribonucleic acid (mRNA) and protein, especially alpha1 collagen. Antisense nucleic acids are effective in inhibiting harmful or ... Read more...
30 Jan 2009 Classic Ehlers-Danlos syndrome (EDS) is a heritable connective tissue disease characterized by skin hyperextensibility, atrophic scarring, joint hypermobility and generalized tissue fragility. Mutations in COL5A1 and COL5A2, encoding the type V ... Read more...
Latest indexed articles for 'Collagen Type V - Genetics'
These are the very latest articles for this heading:
- Molecular mechanisms of classical Ehlers-Danlos syndrome (EDS). 30 May 2009
- Attenuation of alpha1 collagen production with antisense ribonucleic acid in cultured hypertrophic scar fibroblasts. 29 Apr 2009
- COL5A1 signal peptide mutations interfere with protein secretion and cause classic Ehlers-Danlos syndrome. 30 Jan 2009
- Absence of apparent disease causing mutations in COL5A3 in 13 patients with hypermobility Ehlers-Danlos syndrome.
13 Dec 2008 - Effects of a bioscaffold on collagen fibrillogenesis in healing medial collateral ligament in rabbits. 30 Jul 2008
- A glycine-valine substitution in alpha2 type V procollagen associated with recurrent cervical artery dissection. 25 Jun 2008
- Regulation by P2X7: epithelial migration and stromal organization in the cornea.
21 May 2008 - Rescue of migratory defects of Ehlers-Danlos syndrome fibroblasts in vitro by type V collagen but not insulin-like binding protein-1. 26 Feb 2008
- Genetic aspects of tendinopathy. 15 Sep 2007
- Temporal extracellular matrix adaptations in ligament during wound healing and hindlimb unloading. 13 Aug 2007
- Genetics: does it play a role in tendinopathy? 29 Jun 2007
- Comparative in vitro studies on the fibrogenic effects of two samples of silica on epithelial bronchial cells. 30 Dec 2006
- ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development. 29 Nov 2006
- A comprehensive study of the spatial and temporal expression of the col5a1 gene in mouse embryos: a clue for understanding collagen V function in developing connective tissues. 4 Oct 2006
- Extracellular matrix containing mutated fibrillin-1 (Fbn1) down regulates Col1a1, Col1a2, Col3a1, Col5a1, and Col5a2 mRNA levels in Tsk/+ and Tsk/Tsk embryonic fibroblasts. 2 Apr 2006
- Murine model of the Ehlers-Danlos syndrome. col5a1 haploinsufficiency disrupts collagen fibril assembly at multiple stages. 18 Feb 2006
- Structural abnormalities of the cornea and lid resulting from collagen V mutations. 30 Jan 2006
- The COL5A1 gene and Achilles tendon pathology. 30 Jan 2006
- Glypican-1 and alpha4(V) collagen are required for Schwann cell myelination. 9 Jan 2006
- Molecular genetics in classic Ehlers-Danlos syndrome. 13 Nov 2005
See a longer list of these articles.
Technical information about 'Collagen Type V'
Definition: A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.
Registry Number: 0
Descriptor UI: D024062
Alternative terms: Collagen Type V; Type V Collagen; Collagen, Type V; Collagen Type V, alpha3 Subunit; Collagen Type V, alpha3 Chain; Collagen alpha3(V); Collagen Type V, alpha2 Subunit; Collagen Type V, alpha2 Chain; Collagen alpha2(V); Procollagen Type V; Type V Procollagen; Procollagen, Type V; V Procollagen, Type; Collagen Type V, alpha1 Subunit; Collagen Type V, alpha1 Chain; Collagen alpha1(V);
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D05.750.078.280.300.400; D12.776.860.300.250.300.400;
History Note: 2002; use COLLAGEN 1990-2001; for PROCOLLAGEN TYPE V use PROCOLLAGEN 1983-2001
Technical Notes: precursors: coord IM with PROCOLLAGEN (IM)