Colorectal Neoplasms
Research News and Information

Sunday, November 22, 2009

Epigenetic regulation of microRNA expression in colorectal cancer.

29 Nov 2009 In the last years, microRNAs (miRNA) have emerged as new molecular players involved in carcinogenesis. Deregulation of miRNAs expression has been shown in different human cancer but the molecular mechanism underlying the alteration of miRNA ... Read more...

Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines.

13 Nov 2009 Mutations in KRAS or BRAF frequently manifest in constitutive activation of the MEK1/2-ERK1/2 signalling pathway. The MEK1/2-selective inhibitor, AZD6244 (ARRY-142886), blocks ERK1/2 activation and is currently undergoing clinical evaluation. Tumour ... Read more...

Evaluation of venous invasion by Elastica van Gieson stain and tumor budding predicts local and distant metastases in patients with T1 stage colorectal cancer.

30 Oct 2009 Evaluation of pathologic predictors of metastases in T1 stage colorectal cancer may be difficult with hematoxylin and eosin (HE) staining alone. The aim of this study was to clarify the role of pathologic predictors by using immunohistochemical ... Read more...

Latest indexed articles for 'Colorectal Neoplasms'

These are the very latest articles for this heading:

• Novel multiple, monoallelic KRAS mutations at codon 12 and 13. 29 Nov 2009
• Epigenetic regulation of microRNA expression in colorectal cancer. 29 Nov 2009
• Intrinsic resistance to the MEK1/2 inhibitor AZD6244 (ARRY-142886) is associated with weak ERK1/2 signalling and/or strong PI3K signalling in colorectal cancer cell lines. 13 Nov 2009
• Comparison of time trends in colorectal cancer mortality (1990-2006) in the world, from the WHO mortality database. 30 Oct 2009
• Evaluation of venous invasion by Elastica van Gieson stain and tumor budding predicts local and distant metastases in patients with T1 stage colorectal cancer. 30 Oct 2009
• Association of polymorphisms in regulatory regions of interleukin-12p40 gene and cytokine serum level with colorectal cancer. 30 Oct 2009
• Combination of vandetanib, radiotherapy, and irinotecan in the LoVo human colorectal cancer xenograft model. 30 Oct 2009
• Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model. 30 Oct 2009
• Attenuation of proteolysis-mediated cyclin E regulation by alternatively spliced Parkin in human colorectal cancers. 30 Oct 2009
• E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells. 30 Oct 2009
• Cancer incidence in Israeli Jewish survivors of World War II. 24 Oct 2009
• Cancer risk from extreme stressors: lessons from European Jewish survivors of World War II. 24 Oct 2009
• Meta- and pooled analyses of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and colorectal cancer: a HuGE-GSEC review. 19 Oct 2009
• Differences in colon adenomas and carcinomas among women and men: potential clinical implications. 19 Oct 2009
• Capsule endoscopy versus colonoscopy. 13 Oct 2009
• Capsule endoscopy versus colonoscopy. 13 Oct 2009
• The association between -1304T>G polymorphism in the promoter of MKK4 gene and the risk of sporadic colorectal cancer in southern Chinese population. 13 Oct 2009
• Computed tomographic colonography for detecting advanced neoplasia. 12 Oct 2009
• Computed tomographic colonography for detecting advanced neoplasia. 12 Oct 2009
• Glasgow Prognostic Score as a predictive factor differentiating surgical site infection and remote infection following colorectal cancer surgery? 4 Oct 2009

See a longer list of these articles.

Technical information about 'Colorectal Neoplasms'

Definition: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.

Descriptor UI: D015179

Alternative terms: Colorectal Neoplasms; Colorectal Tumors; Colorectal Tumor; Tumor, Colorectal; Tumors, Colorectal; Neoplasms, Colorectal; Colorectal Neoplasm; Neoplasm, Colorectal; Colorectal Carcinoma; Carcinoma, Colorectal; Carcinomas, Colorectal; Colorectal Carcinomas; Colorectal Cancer; Cancer, Colorectal; Cancers, Colorectal; Colorectal Cancers;

Related Mesh Headings: Genes, DCC; Genes, MCC;

Allowable Qualifiers: blood; blood supply; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; secondary; secretion; surgery; therapy; ultrastructure; urine; veterinary; ultrasonography; chemistry; virology;

Tree Number: C04.588.274.476.411.307; C06.301.371.411.307; C06.405.249.411.307; C06.405.469.158.356; C06.405.469.491.307; C06.405.469.860.180;

History Note: 89

Technical Notes: a clinical entity: not a synonym for COLONIC NEOPLASMS + RECTAL NEOPLASMS; coord IM with histol type of neopl (IM); GENES, DCC (for "Deleted in Colorectal Cancer") & GENES, MCC (for "Mutated in Colorectal Cancer") are available: see MeSH scope notes and annotations there