Computational Biology - Methods
Research News and Information

Saturday, November 21, 2009

Template-free protein structure prediction and quality assessment with an all-atom free-energy model.

30 Oct 2009 Biophysical forcefields have contributed less than originally anticipated to recent progress in protein structure prediction. Here, we have investigated the selectivity of a recently developed all-atom free-energy forcefield for protein structure ... Read more...

Computational methods for discovering structural variation with next-generation sequencing.

30 Oct 2009 In the last several years, a number of studies have described large-scale structural variation in several genomes. Traditionally, such methods have used whole-genome array comparative genome hybridization or single-nucleotide polymorphism arrays to ... Read more...

Modification of protein crystal packing by systematic mutations of surface residues: implications on biotemplating and crystal porosity.

13 Oct 2009 Bioinspired nano-scale biotemplating for the development of novel composite materials has recently culminated in several demonstrations of nano-structured hybrid materials. Protein crystals, routinely prepared for the elucidation of protein 3D ... Read more...

Latest indexed articles for 'Computational Biology - Methods'

These are the very latest articles for this heading:

• Template-free protein structure prediction and quality assessment with an all-atom free-energy model. 30 Oct 2009
• Computational methods for discovering structural variation with next-generation sequencing. 30 Oct 2009
• Modification of protein crystal packing by systematic mutations of surface residues: implications on biotemplating and crystal porosity. 13 Oct 2009
• Discovery of new inhibitors of resistant Streptococcus pneumoniae penicillin binding protein (PBP) 2x by structure-based virtual screening. 6 Oct 2009
• The word landscape of the non-coding segments of the Arabidopsis thaliana genome. 6 Oct 2009
• Characterization of unknown genetic modifications using high throughput sequencing and computational subtraction. 6 Oct 2009
• Proteomic study of neuron and astrocyte cultures from senescence-accelerated mouse SAMP8 reveals degenerative changes. 5 Oct 2009
• Are there any more ovarian tumor suppressor genes? A new perspective using ultra high-resolution copy number and loss of heterozygosity analysis. 29 Sep 2009
• A novel method for predicting and using distance constraints of high accuracy for refining protein structure prediction. 29 Sep 2009
• X-ray vs. NMR structures as templates for computational protein design. 29 Sep 2009
• Beyond the Twilight Zone: automated prediction of structural properties of proteins by recursive neural networks and remote homology information. 29 Sep 2009
• In silico characterization of protein chimeras: relating sequence and function within the same fold. 29 Sep 2009
• Prediction of protein-glucose binding sites using support vector machines. 29 Sep 2009
• Automated scaffold selection for enzyme design. 29 Sep 2009
• Structural bioinformatics mutation analysis reveals genotype-phenotype correlations in von Hippel-Lindau disease and suggests molecular mechanisms of tumorigenesis. 29 Sep 2009
• Computational protein design as a tool for fold recognition. 29 Sep 2009
• Identifying native-like protein structures with scoring functions based on all-atom ECEPP force fields, implicit solvent models and structure relaxation. 29 Sep 2009
• Automated site preparation in physics-based rescoring of receptor ligand complexes. 29 Sep 2009
• Dynamic computation of incentive salience: "wanting" what was never "liked". 28 Sep 2009
• A robust method for searching the smallest set of smallest rings with a path-included distance matrix. 22 Sep 2009

See a longer list of these articles.

Technical information about 'Computational Biology'

Definition: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories applicable to MOLECULAR BIOLOGY and areas of computer-based techniques for solving biological problems including manipulation of models and datasets.

Descriptor UI: D019295

Alternative terms: Computational Biology; Biology, Computational; Bio-Informatics; Bioinformatics; Computational Molecular Biology; Molecular Biology, Computational;

Related Mesh Headings: Medical Informatics;

Allowable Qualifiers: classification; economics; education; history; instrumentation; legislation & jurisprudence; manpower; methods; organization & administration; standards; trends; statistics & numerical data; ethics;

Tree Number: H01.158.273.180;

History Note: 97

Technical Notes: SPEC; SPEC qualif; coord IM with specific biol spec (IM); DF: COMPUTATIONAL BIOL