Connective Tissue Growth Factor - Metabolism
Research News and Information

Monday, November 23, 2009

Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature.

29 Sep 2009 An amphetamine (AMPH) regimen that does not produce a prominent blood-brain barrier breakdown was shown to significantly alter the expression of genes regulating vascular tone, immune function, and angiogenesis in vasculature associated with ... Read more...

Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion.

13 Aug 2009 Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies, due mainly to the prevalence of undetected metastatic disease. The process of cell invasion during intraperitoneal anchoring of metastatic lesions requires ... Read more...

Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function.

12 Aug 2009 AIM: To determine the effect of hammerhead ribozyme targeting connective tissue growth factor (CCN2) on human hepatic stellate cell (HSC) function. METHODS: CCN2 hammerhead ribozyme cDNA plus two self-cleaving sequences were inserted into pTriEx2 to ... Read more...

Latest indexed articles for 'Connective Tissue Growth Factor - Metabolism'

These are the very latest articles for this heading:

• Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. 29 Sep 2009
• Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. 13 Aug 2009
• Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function. 12 Aug 2009
• Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3. 8 Aug 2009
• Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. 3 Aug 2009
• Established neointimal hyperplasia in vein grafts expands via TGF-beta-mediated progressive fibrosis. 15 Jul 2009
• Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. 29 Jun 2009
• Effects of pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 in radiation-induced intestinal injury. 29 Jun 2009
• Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway. 13 Jun 2009
• Skin disease: a cardinal feature of systemic sclerosis. 30 May 2009
• TNF-alpha suppressed TGF-beta-induced CTGF expression by switching the binding preference of p300 from Smad4 to p65. 30 May 2009
• Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells. 29 May 2009
• Non-invasive biomarkers for monitoring the fibrogenic process in liver: a short survey. 26 May 2009
• N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan. 25 May 2009
• Increased MMP-3 and CTGF expression during lipopolysaccharide-induced dopaminergic neurodegeneration. 18 May 2009
• CTGF enhances migration and MMP-13 up-regulation via alphavbeta3 integrin, FAK, ERK, and NF-kappaB-dependent pathway in human chondrosarcoma cells. 13 May 2009
• Adverse effects of nicotine and immunosuppression on proximal tubular epithelial cell viability, tissue repair and oxidative stress gene expression. 3 May 2009
• The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea. 29 Apr 2009
• Osteogenic differentiation of mesenchymal stem cells promoted by overexpression of connective tissue growth factor. 29 Apr 2009
• Simvastatin impairs smad-3 phosphorylation and modulates transforming growth factor beta1-mediated activation of intestinal fibroblasts. 29 Apr 2009

See a longer list of these articles.

Technical information about 'Connective Tissue Growth Factor'

Definition: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.

Registry Number: 139568-91-5

Descriptor UI: D055513

Alternative terms: Connective Tissue Growth Factor; Hypertrophic Chondrocyte-Specific Protein 24; Hypertrophic Chondrocyte Specific Protein 24; IGF-Binding Protein-Related Protein-2; IGF Binding Protein Related Protein 2; IGFBP-rP2; Insulin-Like Growth Factor Binding Protein 8; Insulin Like Growth Factor Binding Protein 8; CCN2 Protein; IGFBP-8;

Allowable Qualifiers: ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity;

Tree Number: D12.644.276.200.100; D12.776.467.200.100; D12.776.860.300.200.100; D23.529.237.100;

History Note: 2009(1991)