Connective Tissue Growth Factor
Research News and Information

Monday, November 23, 2009

Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes.

10 Oct 2009 Abnormal fibrosis occurs during chronic hepatic inflammations and is the principal cause of death in hepatitis C virus and schistosome infections. Hepatic fibrosis (HF) may develop either slowly or rapidly in schistosome-infected subjects. This ... Read more...

Gene expression profile of residual breast cancer after doxorubicin and cyclophosphamide neoadjuvant chemotherapy.

29 Sep 2009 In breast cancer patients, primary chemotherapy is associated with the same survival benefits as adjuvant chemotherapy. Residual tumors represent a clinical challenge, as they may be resistant to additional cycles of the same drugs. Our aim was to ... Read more...

Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature.

29 Sep 2009 An amphetamine (AMPH) regimen that does not produce a prominent blood-brain barrier breakdown was shown to significantly alter the expression of genes regulating vascular tone, immune function, and angiogenesis in vasculature associated with ... Read more...

Latest indexed articles for 'Connective Tissue Growth Factor'

These are the very latest articles for this heading:

• Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes. 10 Oct 2009
• Gene expression profile of residual breast cancer after doxorubicin and cyclophosphamide neoadjuvant chemotherapy. 29 Sep 2009
• Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature. 29 Sep 2009
• Susceptibility to liver fibrosis in mice expressing a connective tissue growth factor transgene in hepatocytes. 30 Aug 2009
• Less Smad2 is good for you! A scientific update on coffee's liver benefits. 30 Aug 2009
• Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. 13 Aug 2009
• Connective tissue growth factor hammerhead ribozyme attenuates human hepatic stellate cell function. 12 Aug 2009
• Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3. 8 Aug 2009
• Omega-3 fatty acid supplementation attenuates oxidative stress, inflammation, and tubulointerstitial fibrosis in the remnant kidney. 3 Aug 2009
• Established neointimal hyperplasia in vein grafts expands via TGF-beta-mediated progressive fibrosis. 15 Jul 2009
• Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts. 7 Jul 2009
• Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen. 29 Jun 2009
• Effects of pharmacological inhibition and genetic deficiency of plasminogen activator inhibitor-1 in radiation-induced intestinal injury. 29 Jun 2009
• Role of connective tissue growth factor and its interaction with basic fibroblast growth factor and macrophage chemoattractant protein-1 in skin fibrosis. 29 Jun 2009
• Deletion of LOX-1 attenuates renal injury following angiotensin II infusion. 22 Jun 2009
• Thrombin-induced connective tissue growth factor expression in human lung fibroblasts requires the ASK1/JNK/AP-1 pathway. 13 Jun 2009
• Tgf-beta auto-induction and connective tissue growth factor expression in human renal tubule epithelial cells requires N-ras. 30 May 2009
• [Study on correlation between connective tissue growth factor, macrophage colony-stimulating factor and cartilage degeneration in the osteoarthritis chondrocytes] 30 May 2009
• Skin disease: a cardinal feature of systemic sclerosis. 30 May 2009
• Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes--but without modulating bone morphogenetic protein 7 signaling. 30 May 2009

See a longer list of these articles.

Technical information about 'Connective Tissue Growth Factor'

Definition: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.

Registry Number: 139568-91-5

Descriptor UI: D055513

Alternative terms: Connective Tissue Growth Factor; Hypertrophic Chondrocyte-Specific Protein 24; Hypertrophic Chondrocyte Specific Protein 24; IGF-Binding Protein-Related Protein-2; IGF Binding Protein Related Protein 2; IGFBP-rP2; Insulin-Like Growth Factor Binding Protein 8; Insulin Like Growth Factor Binding Protein 8; CCN2 Protein; IGFBP-8;

Allowable Qualifiers: ultrastructure; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity;

Tree Number: D12.644.276.200.100; D12.776.467.200.100; D12.776.860.300.200.100; D23.529.237.100;

History Note: 2009(1991)