Corpus Striatum - Metabolism
Research News and Information

Saturday, November 21, 2009

Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor.

29 Sep 2009 The glutamate agonist LY404,039 has been used to treat schizophrenia. Because all currently used antipsychotics act on dopamine receptors, it was decided to examine whether this glutamate agonist also had an affinity for dopamine D2 receptors in ... Read more...

C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity.

29 Sep 2009 The C957T polymorphism of the human dopamine D2 receptor gene (DRD2) regulates DRD2 availability in striatum in vivo. Specifically, the T allele predicts high DRD2 availability in healthy volunteers (T/T>T/C>C/C). However, this finding was ... Read more...

Striatal expression of a calmodulin fragment improved motor function, weight loss, and neuropathology in the R6/2 mouse model of Huntington's disease.

14 Sep 2009 Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a polyglutamine expansion in the huntingtin protein (htt). Increasing evidence suggests that transglutaminase (TGase) plays a critical role in the ... Read more...

Latest indexed articles for 'Corpus Striatum - Metabolism'

These are the very latest articles for this heading:

• Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor. 29 Sep 2009
• C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity. 29 Sep 2009
• Striatal expression of a calmodulin fragment improved motor function, weight loss, and neuropathology in the R6/2 mouse model of Huntington's disease. 14 Sep 2009
• Regulation of kinesin light chain 1 level correlates with the development of morphine reward in the mouse brain. 2 Sep 2009
• Lower level of endogenous dopamine in patients with cocaine dependence: findings from PET imaging of D(2)/D(3) receptors following acute dopamine depletion. 30 Aug 2009
• Dopamine release at individual presynaptic terminals visualized with FFNs. 29 Aug 2009
• Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats. 25 Aug 2009
• Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. 25 Aug 2009
• Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats. 15 Aug 2009
• Increase of striatal dopamine transmission in first episode drug-naive schizophrenic patients as demonstrated by [(123)I]IBZM SPECT. 13 Aug 2009
• Increased levels of proinflammatory cytokines in the aged rat brain attenuate injury-induced cytokine response after excitotoxic damage. 13 Aug 2009
• Natural lipophilic inhibitors of mitochondrial complex I are candidate toxins for sporadic neurodegenerative tau pathologies. 11 Aug 2009
• The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice. 11 Aug 2009
• Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain. 8 Aug 2009
• Restriction of dopamine signaling to the dorsolateral striatum is sufficient for many cognitive behaviors. 8 Aug 2009
• Distinct neuroinflammatory profile in post-mortem human Huntington's disease. 3 Aug 2009
• [Hemichorea-hemiballism associated to non-ketonic hyperglycemia with striatal hyperintensity] 30 Jul 2009
• Should I stay or should I go: genetic bases for uncertainty-driven exploration. 30 Jul 2009
• Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil. 30 Jul 2009
• Acquisition of and withdrawal from cocaine self-administration regulates 5-HT mRNA expression in rat striatum. 28 Jul 2009

See a longer list of these articles.

Technical information about 'Corpus Striatum'

Definition: Striped gray and white matter consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the thalamus in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The white matter is the internal capsule.

Descriptor UI: D003342

Alternative terms: Corpus Striatum; Striatum, Corpus; Lenticular Nucleus; Nucleus, Lenticular; Nucleus Lentiformis; Lentiformis, Nucleus; Lentiform Nucleus; Nucleus, Lentiform;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A08.186.211.730.885.287.249.487;

Online Note: use CORPUS STRIATUM to search LENTICULAR NUCLEUS 1974-78; use BASAL GANGLIA 1966-73

History Note: 74(72); LENTICULAR NUCLEUS was see under CORPUS STRIATUM 1974-78; was see under GANGLIA, BASAL 1963-73

Technical Notes: do not confuse with STRIATE CORTEX see VISUAL CORTEX or VENTRAL STRIATUM see BASAL GANGLIA