Corticosterone - Toxicity
Research News and Information

Monday, November 23, 2009

Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression.

26 May 2009 Understanding the physiopathology of affective disorders and their treatment relies on the availability of experimental models that accurately mimic aspects of the disease. Here we describe a mouse model of an anxiety/depressive-like state induced ... Read more...

Dissecting the pathophysiology of depression with a Swiss army knife.

26 May 2009 In this issue of Neuron, Hen and colleagues shed new light on the behavioral effects of fluoxetine, one of the most commonly prescribed antidepressants. This report prompts us to revisit our understanding of the neural circuitry mediating mood ... Read more...

Teratogenic effects of chronic treatment with corticosterone on tadpoles of Xenopus laevis.

30 Mar 2009 The present study investigated effects of chronic treatment with corticosterone (B) on larval development of the amphibian Xenopus laevis. Tadpoles (stage 51) were treated with B (100, 500 nmol/L), 50 mg/L of the anti-thyroidal substance ... Read more...

Latest indexed articles for 'Corticosterone - Toxicity'

These are the very latest articles for this heading:

• Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression. 26 May 2009
• Dissecting the pathophysiology of depression with a Swiss army knife. 26 May 2009
• Teratogenic effects of chronic treatment with corticosterone on tadpoles of Xenopus laevis. 30 Mar 2009
• Peony glycosides protect against corticosterone-induced neurotoxicity in PC12 cells. 10 Feb 2009
• Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: possible involvement of the ERK1/2 pathway. 18 Jan 2009
• The challenge of continuous exogenous glucocorticoid administration in mice. 19 Nov 2008
• Stressed mothers lay eggs with high corticosterone levels which produce low-quality offspring. 30 Oct 2005
• Glucocorticoid enhances the neurotoxic actions of quinolinic acid in the striatum in a cell-specific manner. 29 Jun 2005
• Neither non-contingent electric footshock nor administered corticosterone facilitate the acquisition of methamphetamine self-administration. 6 Jan 2005
• Choline exposure reduces potentiation of N-methyl-D-aspartate toxicity by corticosterone in the developing hippocampus. 23 Nov 2004
• Chronic administration of corticosterone impairs spatial reference memory before spatial working memory in rats. 29 Jun 2003
• The exacerbation of hippocampal excitotoxicity by glucocorticoids is not mediated by apoptosis. 30 Dec 2002
• Correlation between mitochondrial membrane potential and neurotoxic effect of corticosterone on primary cultured hippocampal cells. 29 Nov 2001
• Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress. 7 Feb 2001
• Chronic corticosterone impairs inhibitory avoidance in rats: possible link with atrophy of hippocampal CA3 neurons. 30 May 2000
• Corticosterone impairs cultured hippocampal neurons and facilitates Ca2+ influx through voltage-dependent Ca2+ channel. 30 Jan 2000
• Brain-derived neurotrophic factor prevents neuronal cell death induced by corticosterone. 13 Jul 1999
• Glucocorticoids interact with gp120 in causing neurotoxicity in striatal cultures. 17 Oct 1998
• Effects of corticosterone on reproduction in male Sprague-Dawley rats. 30 Oct 1997
• Disruption of Th1/Th2 cytokine balance by cocaine is mediated by corticosterone. 30 Jul 1997

See a longer list of these articles.

Technical information about 'Corticosterone'

Definition: An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)

Chemical name: Pregn-4-ene-3,20-dione, 11,21-dihydroxy-, (11beta)-

Registry Number: 50-22-6

Descriptor UI: D003345

Alternative terms: Corticosterone;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Anti-Inflammatory Agents;

Tree Number: D04.808.745.745.654.237; D06.472.040.585.353.237;

Technical Notes: /biosyn /physiol permitted