Corticotropin-Releasing Hormone - Pharmacology
Research News and Information

Monday, November 23, 2009

Corticotropin-releasing factor receptor antagonism within the dorsal raphe nucleus reduces social anxiety-like behavior after early-life social isolation.

10 Aug 2009 Social isolation of rats during the early part of development increases social anxiety-like behavior in adulthood. Furthermore, early-life social isolation increases the levels of corticotropin-releasing factor (CRF) receptors in the serotonergic ... Read more...

Effects of corticoliberin on synaptic transmission in rat olfactory cortex slices in a water immersion model of depression.

19 Jul 2009 Corticoliberin (corticotrophin-releasing factor, CRF, CRH) is an active regulator of endocrine, autonomic, and immune functions in stress, as well as a mediator of anxiety, determining the behavioral stress response. The present report describes ... Read more...

Hypothalamic neuronal histamine signaling in the estrogen deficiency-induced obesity.

6 Jul 2009 Menopause is one of the triggers that induce obesity. Estradiol (E2), corticotropin-releasing hormone (CRH), and hypothalamic neuronal histamine are anorexigenic substances within the hypothalamus. This study examined the interactions among E2, CRH, ... Read more...

Latest indexed articles for 'Corticotropin-Releasing Hormone - Pharmacology'

These are the very latest articles for this heading:

• Corticotropin-releasing factor receptor antagonism within the dorsal raphe nucleus reduces social anxiety-like behavior after early-life social isolation. 10 Aug 2009
• Effects of corticoliberin on synaptic transmission in rat olfactory cortex slices in a water immersion model of depression. 19 Jul 2009
• Hypothalamic neuronal histamine signaling in the estrogen deficiency-induced obesity. 6 Jul 2009
• Nitric oxide synthase isozymes in spinally projecting PVN neurons are involved in CRF-induced sympathetic activation. 13 Jun 2009
• Interaction between the effects of corticotropin-releasing factor and prepulse parameters on prepulse inhibition in two inbred rat strains and the F1 generation of a cross between them. 6 Jun 2009
• The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability. 2 Jun 2009
• Corticotropin Releasing Factor promotes breast cancer cell motility and invasiveness. 31 May 2009
• Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. 18 May 2009
• The role of store-operated Ca2+ channels in adrenocorticotropin release by rat pituitary cells. 11 May 2009
• Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway. 7 May 2009
• Central administration of obestatin fails to show inhibitory effects on food and water intake in mice. 3 May 2009
• Urotensin I-CRF-Urocortins: a mermaid's tail. 2 May 2009
• Corticotropin-releasing hormone and mast cells in the regulation of mucosal barrier function in the human colon. 29 Apr 2009
• Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor. 29 Apr 2009
• The effects of apelin on hypothalamic-pituitary-adrenal axis neuroendocrine function are mediated through corticotrophin-releasing factor- and vasopressin-dependent mechanisms. 22 Apr 2009
• Cardiovascular responses to microinjections of urocortins into the NTS: role of inotropic glutamate receptors. 22 Apr 2009
• Dex/CRH test cortisol response in outpatients with major depression and matched healthy controls. 15 Apr 2009
• [Chronic administration of CRF makes depression like changes in rats] 30 Mar 2009
• Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals. 30 Mar 2009
• Effects of AVP V1a and CRH receptor antagonist on psychological stress responses to frustrating condition in sheep. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Corticotropin-Releasing Hormone'

Definition: A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

Registry Number: 9015-71-8

Descriptor UI: D003346

Alternative terms: Corticotropin-Releasing Hormone; Corticotropin Releasing Hormone; ACTH-Releasing Hormone; ACTH Releasing Hormone; Corticoliberin; CRF-41; Corticotropin-Releasing Factor-41; Corticotropin Releasing Factor 41; Corticotropin-Releasing Hormone-41; Corticotropin Releasing Hormone 41; CRF (ACTH); ACTH-Releasing Factor; ACTH Releasing Factor; Corticotropin-Releasing Factor; Corticotropin Releasing Factor;

Related Mesh Headings: Receptors, Corticotropin-Releasing Hormone;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Hormones;

Tree Number: D06.472.699.327.740.140; D12.644.400.400.740.140; D12.644.548.365.740.140; D12.776.641.650.405.740.140;

Online Note: use CORTICOTROPIN-RELEASING HORMONE to search CORTICOTROPIN RELEASING HORMONE 1974-89 & CORTICOTROPIN RELEASING FACTOR 1968-73

History Note: 90; was CORTICOTROPIN RELEASING HORMONE 1974-89; was CORTICOTROPIN RELEASING FACTOR 1968-73

Technical Notes: DF: CRH