Coumarins - Pharmacology
Research News and Information

Sunday, November 22, 2009

Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida.

30 Aug 2009 Two new sesquiterpene coumarins, designated 5'-acetoxy-8'-hydroxyumbelliprenin (1) and 10'R-acetoxy-11'-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a ... Read more...

Cytotoxic constituents of Soymida febrifuga from Myanmar.

30 Aug 2009 The 70% ethanol extract of Soymida febrifuga was found to kill PANC-1 human pancreatic cancer cells preferentially under nutrition-deprived conditions at a concentration of 10 microg/mL. Phytochemical investigation led to the isolation of 27 ... Read more...

Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4.

30 Aug 2009 A new cyclic acetal (1) of marmin (6',7'-dihydroxy-7-geranyloxycoumarin), two new cyclic acetals (5, 6) of 6',7'-dihydroxybergamottin, and the known compounds marmin (2), 7-geranyloxycoumarin (3), bergamottin (4), and 6',7'-dihydroxybergamottin (7) ... Read more...

Latest indexed articles for 'Coumarins - Pharmacology'

These are the very latest articles for this heading:

• Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida. 30 Aug 2009
• Cytotoxic constituents of Soymida febrifuga from Myanmar. 30 Aug 2009
• Minor furanocoumarins and coumarins in grapefruit peel oil as inhibitors of human cytochrome P450 3A4. 30 Aug 2009
• Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice. 10 Aug 2009
• Efficacy of coumarin on hepatic key enzymes of glucose metabolism in chemical induced type 2 diabetic rats. 4 Aug 2009
• Anti-inflammatory activity and possible mechanism of extract from Mikania laevigata in carrageenan-induced peritonitis. 30 Jul 2009
• Induction of quinone reductase activity by psoralidin isolated from Psoralea corylifolia in mouse hepa 1c1c7 cells. 29 Jul 2009
• Coumarins from Angelica lucida L.--antibacterial activities. 25 Jul 2009
• Tyrosinase inhibitor activity of coumarin-resveratrol hybrids. 11 Jul 2009
• Design and synthesis of some thiazolidin-4-ones based on (7-hydroxy-2-oxo-2H-chromen-4-yl) acetic acid. 8 Jul 2009
• Coumestan glycosides from the stem bark of Cylicodiscus gabunensis. 29 Jun 2009
• Dissimilar in vitro and in vivo effects of ellagic acid and its microbiota-derived metabolites, urolithins, on the cytochrome P450 1A1. 22 Jun 2009
• Anti-inflammatory effect of coumarins isolated from Corydalis heterocarpa in HT-29 human colon carcinoma cells. 11 Jun 2009
• Lamellarin D bioconjugates II: Synthesis and cellular internalization of dendrimer and nuclear location signal derivatives. 30 May 2009
• Lamellarin D bioconjugates I: Synthesis and cellular internalization of PEG-derivatives. 30 May 2009
• Gene expression, cell cycle arrest and MAPK signalling regulation in Caco-2 cells exposed to ellagic acid and its metabolites, urolithins. 30 May 2009
• Inhibition of Mek 1/2 kinase activity and stimulation of melanogenesis by 5,7-dimethoxycoumarin treatment of melanoma cells. 30 May 2009
• Microtubule involvement in the deposition of radial fibrillar callose arrays in stomata of the fern Asplenium nidus L. 30 May 2009
• Chemical constituents from the aerial parts of Artemisia minor. 30 May 2009
• Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. 30 May 2009

See a longer list of these articles.

Technical information about 'Coumarins'

Definition: Synthetic or naturally occurring substances related to coumarin, the delta-lactone of coumarinic acid. The various coumarins have a wide range of proposed actions and uses including as ANTICOAGULANTS, pharmaceutical aids, indicators and reagents, photoreactive substances, and ANTINEOPLASTIC AGENTS.

Registry Number: 0

Descriptor UI: D003374

Alternative terms: Coumarins; Benzopyran-2-ones; Benzopyran 2 ones; Coumarines; 1,2-Benzo-Pyrones; 1,2 Benzo Pyrones; 1,2-Benzopyrones; 1,2 Benzopyrones;

Related Mesh Headings: Anticoagulants; Indicators and Reagents; Pharmaceutic Aids; Pyrones;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Anticoagulants; Antineoplastic Agents; Indicators and Reagents;

Tree Number: D03.438.150.446; D03.830.219.446;