Cyclic AMP Response Element-Binding Protein - Drug effects
Research News and Information

Sunday, November 22, 2009

Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation.

3 Aug 2009 We have previously shown that simvastatin (Sim) has long-lasting neuroprotective effects in a neonatal model of hypoxia-ischemia. Herein we evaluated the neuroprotective effect of different doses and duration of Sim treatment and further addressed ... Read more...

Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.

12 May 2009 Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly ... Read more...

Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus.

15 Mar 2009 Memory impairment is considered to be one of the most prominent consequences of aging. Deterioration of memory begins in advance of old age in animals, including humans. Thus, it is extremely important to prevent memory decline for increasing ... Read more...

Latest indexed articles for 'Cyclic AMP Response Element-Binding Protein - Drug effects'

These are the very latest articles for this heading:

• Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation. 3 Aug 2009
• Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. 12 May 2009
• Long-term ginsenoside administration prevents memory impairment in aged C57BL/6J mice by up-regulating the synaptic plasticity-related proteins in hippocampus. 15 Mar 2009
• Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference. 9 Feb 2009
• Mitogen-activated protein kinase-signaling stimulates Müller glia to proliferate in acutely damaged chicken retina. 13 Jan 2009
• Levothyroxin restores hypothyroidism-induced impairment of hippocampus-dependent learning and memory: Behavioral, electrophysiological, and molecular studies. 30 Dec 2008
• Central amygdala extracellular signal-regulated kinase signaling pathway is critical to incubation of opiate craving. Dec 2008
• Nicotine suppresses bone sialoprotein gene expression. 9 Nov 2008
• Memantine protects rat cortical cultured neurons against beta-amyloid-induced toxicity by attenuating tau phosphorylation. 30 Oct 2008
• Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL. 29 Sep 2008
• Nerve sprouting suppresses myocardial I(to) and I(K1) channels and increases severity to ventricular fibrillation in rat. 23 Sep 2008
• Estrogen-induced Bcl-2 expression after spinal cord injury is mediated through phosphoinositide-3-kinase/Akt-dependent CREB activation. 30 Aug 2008
• Nicotine-induced phosphorylation of phosphorylated cyclic AMP response element-binding protein (pCREB) in hippocampal neurons is potentiated by agrin. 10 Jul 2008
• Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase inhibition. 30 May 2008
• Fluoxetine increases the activity of the ERK-CREB signal system and alleviates the depressive-like behavior in rats exposed to chronic forced swim stress. 18 May 2008
• Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. 12 May 2008
• Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation. 18 Apr 2008
• Eicosapentaenoic acid stimulates the expression of myelin proteins in rat brain. 28 Feb 2008
• Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. 22 Feb 2008
• L-DOPA-induced activation of striatal p38MAPK and CREB in neonatal dopaminergic denervated rat: relevance to self-injurious behavior. 30 Jan 2008

See a longer list of these articles.

Technical information about 'Cyclic AMP Response Element-Binding Protein'

Definition: A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.

Registry Number: 0

Descriptor UI: D017362

Alternative terms: Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Responsive DNA-Binding Protein; Cyclic AMP Responsive DNA Binding Protein; CREB Protein; DNA-Binding Protein, Cyclic AMP-Responsive; DNA Binding Protein, Cyclic AMP Responsive; cAMP Response Element-Binding Protein; cAMP Response Element Binding Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.260.108.184; D12.776.930.127.184;

Online Note: use DNA-BINDING PROTEIN, CYCLIC AMP-RESPONSIVE (NM) to search CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN 1989-92

History Note: 93; was CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN (NM) 1989-92