Cyclic GMP - Pharmacology
Research News and Information

Monday, March 22, 2010

Impairment of intracerebral arteriole dilation responses after subarachnoid hemorrhage. Laboratory investigation.

30 Oct 2009 OBJECT: Cerebrovascular dysfunction after subarachnoid hemorrhage (SAH) may contribute to ischemia, but little is known about the contribution of intracerebral arterioles. In this study, the authors tested the hypothesis that SAH inhibits the ... Read more...

Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart.

12 Aug 2009 Mechanical load and ischemia induce a series of adaptive physiological responses by activating the expression of O(2)-regulated genes, such as hypoxia inducible factor-1alpha (HIF-1alpha). The aim of this study was to explore the interaction between ... Read more...

Nitric oxide and cGMP signal transduction positively regulates the motility of human neuronal precursor (NT2) cells.

12 Jul 2009 Developmental studies in both vertebrates and invertebrates implicate an involvement of nitric oxide (NO) signaling in cell proliferation, neuronal motility, and synaptic maturation. However, it is unknown whether NO plays a role in the development ... Read more...

Latest indexed articles for 'Cyclic GMP - Pharmacology'

These are the very latest articles for this heading:

• Impairment of intracerebral arteriole dilation responses after subarachnoid hemorrhage. Laboratory investigation. 30 Oct 2009
• Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart. 12 Aug 2009
• Nitric oxide and cGMP signal transduction positively regulates the motility of human neuronal precursor (NT2) cells. 12 Jul 2009
• Epac inhibits apoptosis of human leukocytes. 27 Jun 2009
• Involvement of phosphatidylinositol 3-kinase in cAMP- and cGMP-induced duodenal epithelial CFTR activation in mice. 15 Jun 2009
• The nitric oxide-cGMP pathway controls the directional polarity of growth cone guidance via modulating cytosolic Ca2+ signals. 15 Jun 2009
• Activation of the nitric oxide-cGMP pathway reduces phasic contractions in neonatal rat bladder strips via protein kinase G. Jun 2009
• Atrial natriuretic peptide and long-acting natriuretic peptide inhibit ras in human prostate cancer cells. 30 May 2009
• c-di-GMP as a vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylococcus aureus (MRSA) infection. 7 May 2009
• Expression regulation and function of Pref-1 during adipogenesis of human mesenchymal stem cells (MSCs). 5 May 2009
• Protein kinase G is involved in ammonia-induced swelling of astrocytes. 29 Apr 2009
• The Rho-A/Rho-kinase pathway is up-regulated but remains inhibited by cyclic guanosine monophosphate-dependent mechanisms during endotoxemia in small mesenteric arteries. 29 Apr 2009
• Regulation of epithelial sodium channels by cGMP/PKGII. 7 Apr 2009
• Nitric oxide- and cGMP-active compounds affect the discharge of substantia nigra pars reticulata neurons: in vivo evidences in the rat. 5 Apr 2009
• Switching direction in electric-signal-induced cell migration by cyclic guanosine monophosphate and phosphatidylinositol signaling. Apr 2009
• Intraflagellar transport/Hedgehog-related signaling components couple sensory cilium morphology and serotonin biosynthesis in Caenorhabditis elegans. 30 Mar 2009
• Vessel dilator and kaliuretic peptide inhibit Ras in human prostate cancer cells. 30 Mar 2009
• Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation. 12 Mar 2009
• Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. 9 Mar 2009
• SERCA inhibition limits the functional effects of cyclic GMP in both control and hypertrophic cardiac myocytes. 2 Mar 2009

See a longer list of these articles.

Technical information about 'Cyclic GMP'

Definition: Guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. (From Merck Index, 11th ed)

Chemical name: Guanosine, cyclic 3',5'-(hydrogen phosphate)

Registry Number: 7665-99-8

Descriptor UI: D006152

Alternative terms: Cyclic GMP; GMP, Cyclic; Guanosine Cyclic Monophosphate; Cyclic Monophosphate, Guanosine; Monophosphate, Guanosine Cyclic; Guanosine Cyclic 3',5'-Monophosphate; 3',5'-Monophosphate, Guanosine Cyclic; Cyclic 3',5'-Monophosphate, Guanosine; Guanosine Cyclic 3,5 Monophosphate; Guanosine Cyclic-3',5'-Monophosphate; Cyclic-3',5'-Monophosphate, Guanosine; Guanosine Cyclic 3',5' Monophosphate;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D03.438.759.646.454.160; D13.695.462.275; D13.695.667.454.160; D13.695.827.426.160;

Online Note: use CYCLIC GMP to search GUANOSINE CYCLIC MONOPHOSPHATE & GUANOSINE CYCLIC 2',3'-MONOPHOSPHATE 1980-93 & GUANOSINE CYCLIC-3',5'-MONOPHOSPHATE 1971-79 (as Prov 1971)

History Note: 94; was GUANOSINE CYCLIC MONOPHOSPHATE 1980-93, was GUANOSINE CYCLIC-3',5'-MONOPHOSPHATE 1978-79, was GUANOSINE CYCLIC 3',5' MONOPHOSPHATE 1971-77 (Prov 1971); CYCLIC GMP was see GUANOSINE CYCLIC MONOPHOSPHATE 1975-93; GUANOSINE CYCLIC 2',3'-MONOPHOSPHATE was see GUANOSINE CYCLIC MONOPHOSPHATE 1980-93

Technical Notes: /biosyn /physiol permitted; DF: CYCL GMP