Cyclin-Dependent Kinase 5
Research News and Information

Sunday, November 22, 2009

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.

8 Oct 2009 Semaphorin-3A (Sema3A) is an attractive guidance molecule for cortical apical dendrites. To elucidate the role of Sema3A in hippocampal dendritic formation, we examined the Sema3A expression pattern in the perinatal hippocampal formation and ... Read more...

Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo.

5 Oct 2009 Recent evidence suggests that abnormal activation of cyclin-dependent kinase 5 (cdk5) is a critical prodeath signal in stroke. However, the mechanism(s) by which cdk5 promotes death is unclear. Complicating the role of cdk5 are the observations that ... Read more...

Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator.

26 Jul 2009 The dysfunction of proteasomes and mitochondria has been implicated in the pathogenesis of Parkinson disease. However, the mechanism by which this dysfunction causes neuronal cell death is unknown. We studied the role of cyclin-dependent kinase 5 ... Read more...

Latest indexed articles for 'Cyclin-Dependent Kinase 5'

These are the very latest articles for this heading:

• Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice. 8 Oct 2009
• Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo. 5 Oct 2009
• Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 cyclin-dependent kinase 5 activator. 26 Jul 2009
• Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. 21 Jul 2009
• Extrasynaptic NMDA receptors couple preferentially to excitotoxicity via calpain-mediated cleavage of STEP. 20 Jul 2009
• HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes. 19 Jul 2009
• No association of CDK5 genetic variants with Alzheimer's disease risk. 15 Jul 2009
• Examination of type 2 diabetes loci implicates CDKAL1 as a birth weight gene. 8 Jul 2009
• Synthesis and biological evaluation of 3,6-diamino-1H-pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors. Jul 2009
• The Cdk5 inhibitor roscovitine strongly inhibits glucose uptake in 3T3-L1 adipocytes without altering GLUT4 translocation from internal pools to the cell surface. 29 Jun 2009
• Tyrosine kinase nerve growth factor receptor switches from prosurvival to proapoptotic activity via Abeta-mediated phosphorylation. 17 Jun 2009
• Identification of non-muscle myosin heavy chain as a substrate for Cdk5 and tool for drug screening. 15 Jun 2009
• Estrogen-dependent facilitation on spinal reflex potentiation involves the Cdk5/ERK1/2/NR2B cascade in anesthetized rats. 14 Jun 2009
• Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo. 9 Jun 2009
• The D(3) dopamine receptor inhibits dopamine release in PC-12/hD3 cells by autoreceptor signaling via PP-2B, CK1, and Cdk-5. 7 Jun 2009
• Neuroprotective role of Convolvulus pluricaulis on aluminium induced neurotoxicity in rat brain. 4 Jun 2009
• Regulation of hippocampal and behavioral excitability by cyclin-dependent kinase 5. 2 Jun 2009
• Increased CRMP2 phosphorylation is observed in Alzheimer's disease; does this tell us anything about disease development? 30 May 2009
• [Cdk5 regulates various nerve functions] 30 May 2009
• [New role of Cdk5 in oligodendrocytes] 30 May 2009

See a longer list of these articles.

Technical information about 'Cyclin-Dependent Kinase 5'

Definition: A serine-threonine kinase that plays important roles in CELL DIFFERENTIATION; CELL MIGRATION; and CELL DEATH of NERVE CELLS. It is closely related to other CYCLIN-DEPENDENT KINASES but does not seem to participate in CELL CYCLE regulation.

Registry Number: EC 2.7.1.37

Descriptor UI: D051360

Alternative terms: Cyclin-Dependent Kinase 5; Cyclin Dependent Kinase 5; Cdk5 Protein; PSSALRE Protein; Neuronal Cdc2-Like Protein Kinase; Neuronal Cdc2 Like Protein Kinase; Cdc2-Related Kinase PSSALRE; Cdc2 Related Kinase PSSALRE; PSSALRE, Cdc2-Related Kinase; Cdk5 Protein Kinase; Protein Kinase, Cdk5;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682.700.200.067.875; D08.811.913.696.620.682.700.646.500.500.500; D12.644.360.250.067.875; D12.776.167.200.067.875; D12.776.476.250.067.875;

History Note: 2006(1994)