Cyclin-Dependent Kinase Inhibitor p27 - Genetics
Research News and Information

Saturday, March 20, 2010

Transcription factor GATA-3 is essential for lens development.

30 Aug 2009 During vertebrate lens development, the anterior, ectoderm-derived lens vesicle cells differentiate into a monolayer of epithelial cells that retain proliferative potential. Subsequently, they exit the cell cycle and give rise to posterior lens ... Read more...

Xhairy2 functions in Xenopus lens development by regulating p27(xic1) expression.

30 Aug 2009 Lens of vertebrate eyes is derived from competent pre-placodal ectoderm in response to signal(s) from retinal lineage. We herein report that the Xenopus Hes gene Xhairy2, which is expressed in pre-placodal ectoderm, is required for lens development ... Read more...

Functional similarities and uniqueness of p27 and p57: insight from a knock-in mouse model.

20 Aug 2009 The cyclin-dependent kinase inhibitors (CKIs) p27 and p57 are structurally similar, and their biochemical and cellular functions have been thought to be equivalent. However, mice deficient in either p27 or p57 exhibit markedly different phenotypes, ... Read more...

Latest indexed articles for 'Cyclin-Dependent Kinase Inhibitor p27 - Genetics'

These are the very latest articles for this heading:

• Transcription factor GATA-3 is essential for lens development. 30 Aug 2009
• Xhairy2 functions in Xenopus lens development by regulating p27(xic1) expression. 30 Aug 2009
• Functional similarities and uniqueness of p27 and p57: insight from a knock-in mouse model. 20 Aug 2009
• Peroxisome proliferator-activated receptor-gamma is essential in the pathogenesis of gastric carcinoma. 19 Aug 2009
• Regulated expression of cofilin and the consequent regulation of p27(kip1) are essential for G(1) phase progression. 18 Aug 2009
• Unlike p53, p27 failed to exhibit an anti-tumor genetic interaction with Ku80. 9 Aug 2009
• Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer. Aug 2009
• Effects of a novel tripeptide, tyroserleutide (YSL), on cell cycle progression of human hepatocellular carcinoma. 30 Jul 2009
• FoxM1 is up-regulated in gastric cancer and its inhibition leads to cellular senescence, partially dependent on p27 kip1. 30 Jul 2009
• Timing the Phox-trot: duration of Phox2a-dependent transcription is controlled by an intramolecular dephosphorylation/phosphorylation clock. 25 Jul 2009
• PPARdelta-mediated p21/p27 induction via increased CREB-binding protein nuclear translocation in beraprost-induced antiproliferation of murine aortic smooth muscle cells. 6 Jul 2009
• Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process. 5 Jul 2009
• Expression of CRM1 in human gliomas and its significance in p27 expression and clinical prognosis. 29 Jun 2009
• Prognostic significance of p27Kip1, Ki-67, and CRTC1-MAML2 fusion transcript in mucoepidermoid carcinoma: a molecular and clinicopathologic study of 101 cases. 29 Jun 2009
• Time-dependent activation of Phox2a by the cyclic AMP pathway modulates onset and duration of p27Kip1 transcription. 27 Jun 2009
• Mirk regulates the exit of colon cancer cells from quiescence. 17 Jun 2009
• Effect of p27mt gene on apoptosis of the colorectal cancer cell line Lovo. 12 Jun 2009
• The V109G polymorphism in the p27 gene is associated with endometriosis. 31 May 2009
• Growth inhibition of the pulmonary metastatic tumors by systemic delivery of the p27 kip1 gene using lyophilized lipid-polycation-DNA complexes. 30 May 2009
• Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo. 30 May 2009

See a longer list of these articles.

Technical information about 'Cyclin-Dependent Kinase Inhibitor p27'

Definition: A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.

Registry Number: 147604-94-2

Descriptor UI: D050760

Alternative terms: Cyclin-Dependent Kinase Inhibitor p27; Cyclin Dependent Kinase Inhibitor p27; CDKN4 Protein; p27 CDK Inhibitor; CDK Inhibitor, p27; p27 Kip1 Protein; Kip1 Protein, p27; CDKN1B Protein; p27Kip1 Protein; CDK Inhibitor p27; p27, CDK Inhibitor; Cyclin-Dependent Kinase Inhibitor 1B; Cyclin Dependent Kinase Inhibitor 1B;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Pharmacological Action: Protein Kinase Inhibitors;

Tree Number: D12.644.360.225.600; D12.776.167.187.600; D12.776.476.225.600; D12.776.624.776.355.600;

History Note: 2006(1992)