Cyclin-Dependent Kinases - Metabolism
Research News and Information

Sunday, November 22, 2009

Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma.

29 Nov 2009 Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma ... Read more...

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.

6 Sep 2009 In eukaryotes, the activation of the prereplicative complex and assembly of an active DNA unwinding complex are critical but poorly understood steps required for the initiation of DNA replication. In this report, we have used bimolecular ... Read more...

Coupling the cell cycle to development.

30 Aug 2009 The core machinery that drives the eukaryotic cell cycle has been thoroughly investigated over the course of the past three decades. It is only more recently, however, that light has been shed on the mechanisms by which elements of this core ... Read more...

Latest indexed articles for 'Cyclin-Dependent Kinases - Metabolism'

These are the very latest articles for this heading:

• Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. 29 Nov 2009
• Cyclin-dependent kinases: a family portrait. 30 Oct 2009
• Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. 6 Sep 2009
• Coupling the cell cycle to development. 30 Aug 2009
• Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. 18 Aug 2009
• Exploring Rak tyrosine kinase function in breast cancer. 13 Aug 2009
• CDK inhibitors and immune responses. 13 Aug 2009
• TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. 8 Aug 2009
• Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome. 5 Aug 2009
• The licensing checkpoint opens up. 30 Jul 2009
• The regulation of protein phosphorylation. 30 Jul 2009
• Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia? 30 Jul 2009
• A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1. 28 Jul 2009
• Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. 26 Jul 2009
• Transcription factors LSF and E2Fs: tandem cyclists driving G0 to S? 19 Jul 2009
• Cell cycle regulation of the mammalian CDK activator RINGO/Speedy A. 17 Jul 2009
• The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1. 16 Jul 2009
• Pin1 catalyzes conformational changes of Thr-187 in p27Kip1 and mediates its stability through a polyubiquitination process. 5 Jul 2009
• Phosphorylation of the transcription elongation factor Spt5 by yeast Bur1 kinase stimulates recruitment of the PAF complex. 4 Jul 2009
• Mammalian cell-cycle regulation: several Cdks, numerous cyclins and diverse compensatory mechanisms. 27 Jun 2009

See a longer list of these articles.

Technical information about 'Cyclin-Dependent Kinases'

Definition: Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.

Registry Number: EC 2.7.1.37

Descriptor UI: D018844

Alternative terms: Cyclin-Dependent Kinases; Cyclin Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclin Dependent Protein Kinases; cdk Proteins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682.700.200; D08.811.913.696.620.682.700.646.500; D12.644.360.250; D12.776.167.200; D12.776.476.250;

History Note: 95