Cyclin-Dependent Kinases
Research News and Information

Monday, November 23, 2009

Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma.

29 Nov 2009 Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma ... Read more...

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins.

6 Sep 2009 In eukaryotes, the activation of the prereplicative complex and assembly of an active DNA unwinding complex are critical but poorly understood steps required for the initiation of DNA replication. In this report, we have used bimolecular ... Read more...

Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.

6 Sep 2009 BACKGROUND: Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide. METHODS: We examined single nucleotide polymorphisms (SNPs) (n=288) from 39 cell cycle ... Read more...

Latest indexed articles for 'Cyclin-Dependent Kinases'

These are the very latest articles for this heading:

• Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma. 29 Nov 2009
• Cyclin-dependent kinases: a family portrait. 30 Oct 2009
• Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. 6 Sep 2009
• Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. 6 Sep 2009
• Chemoprevention of mouse intestinal tumorigenesis by the cyclin-dependent kinase inhibitor SNS-032. 30 Aug 2009
• Coupling the cell cycle to development. 30 Aug 2009
• Regulated activity of PP2A-B55 delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. 18 Aug 2009
• Exploring Rak tyrosine kinase function in breast cancer. 13 Aug 2009
• CDK inhibitors and immune responses. 13 Aug 2009
• TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. 8 Aug 2009
• Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome. 5 Aug 2009
• CRK7 modifies the MAPK pathway and influences the response to endocrine therapy. Aug 2009
• The licensing checkpoint opens up. 30 Jul 2009
• The regulation of protein phosphorylation. 30 Jul 2009
• Monitoring of long-term effects of resveratrol on cell cycle progression of human HeLa cells after administration of a single dose. 30 Jul 2009
• Roscovitine differentially affects asynchronously growing and synchronized human MCF-7 breast cancer cells. 30 Jul 2009
• Selective cyclin-dependent kinase inhibitors discriminating between cell cycle and transcriptional kinases: future reality or utopia? 30 Jul 2009
• Roscovitine triggers apoptosis in B-cell chronic lymphocytic leukemia cells with similar efficiency as combinations of conventional purine analogs with cyclophosphamide. 30 Jul 2009
• A phosphorylation-independent role for the yeast cyclin-dependent kinase activating kinase Cak1. 28 Jul 2009
• Comparative analysis reveals conserved protein phosphorylation networks implicated in multiple diseases. 26 Jul 2009

See a longer list of these articles.

Technical information about 'Cyclin-Dependent Kinases'

Definition: Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events.

Registry Number: EC 2.7.1.37

Descriptor UI: D018844

Alternative terms: Cyclin-Dependent Kinases; Cyclin Dependent Kinases; Cyclin-Dependent Protein Kinases; Cyclin Dependent Protein Kinases; cdk Proteins;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.913.696.620.682.700.200; D08.811.913.696.620.682.700.646.500; D12.644.360.250; D12.776.167.200; D12.776.476.250;

History Note: 95