Cycloleucine
Research News and Information

Monday, March 15, 2010

LC-NMR and LC-MS identification of an impurity in a novel antifungal drug icofungipen.

23 Mar 2009 Successful use of LC-NMR and LC-MS for rapid identification of an impurity in a novel antifungal drug icofungipen has been demonstrated. Complementary information obtained from the two methods made it possible to determine the structure of A1 prior ... Read more...

Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells.

27 Feb 2009 Methionine adenosyltransferase II (MAT II) is a key enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. Normal resting T lymphocytes have minimal MAT II activity, whereas activated ... Read more...

Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice.

Feb 2009 ETHNOPHARMACOLOGICAL RELEVANCE: Pfaffia glomerata (Spreng) Pedersen (Amaranthaceae) is a medicinal plant known in Brazil as "Paratudo" and "Brazilian ginseng" and is commonly used as tonic, antidiabetic and to treat gastric disorders. AIM OF THE ... Read more...

Latest indexed articles for 'Cycloleucine'

These are the very latest articles for this heading:

• LC-NMR and LC-MS identification of an impurity in a novel antifungal drug icofungipen. 23 Mar 2009
• Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells. 27 Feb 2009
• Involvement of glutamate and cytokine pathways on antinociceptive effect of Pfaffia glomerata in mice. Feb 2009
• Distinct roles of metabotropic glutamate receptor activation on inhibitory signaling in the ventral lateral geniculate nucleus. 26 Jan 2009
• New gas chromatographic method for the enantioseparation of beta-amino acids by a rapid double derivatization technique. 23 Dec 2008
• Adjuvant intra-arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer: a prospective randomized controlled trial. 29 Nov 2008
• Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells. 20 Oct 2008
• Tone-dependent vascular responses to astrocyte-derived signals. 30 Apr 2008
• Parallel kinetic resolution of tert-butyl (RS)-3-oxy-substituted cyclopent-1-ene-carboxylates for the asymmetric synthesis of 3-oxy-substituted cispentacin and transpentacin derivatives. 19 Apr 2008
• A decrease in S-adenosyl-L-methionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1. 13 Apr 2008
• Establishing effective simulation protocols for beta- and alpha/beta-peptides. II. Molecular mechanical (MM) model for a cyclic beta-residue. 9 Apr 2008
• Enantio- and diastereoselective syntheses of cyclic Calpha-tetrasubstituted alpha-amino acids and their use to induce stable conformations in short peptides. 30 Dec 2007
• Acute treatment with 17beta-estradiol attenuates astrocyte-astrocyte and astrocyte-neuron communication. 29 Nov 2007
• Dendritic properties of turtle pyramidal neurons. 26 Nov 2007
• [Recent advances in the study of antifungal lead compounds with new chemical scaffolds] 30 Oct 2007
• Glutamate and its metabotropic receptor in Drosophila clock neuron circuits. 30 Oct 2007
• The glutamate uptake system in presynaptic vesicles: further characterization of structural requirements for inhibitors and substrates. 15 Oct 2007
• Stability of tubular structures based on beta-helical proteins: self-assembled versus polymerized nanoconstructs and wild-type versus mutated sequences. 12 Sep 2007
• Effect of exogenous glutamate and N-Methyl-D-aspartic acid on spontaneous activity of isolated human ureter. 30 Aug 2007
• Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes. 13 Jun 2007

See a longer list of these articles.

Technical information about 'Cycloleucine'

Definition: An amino acid formed by cyclization of leucine. It has cytostatic, immunosuppressive and antineoplastic activities.

Chemical name: Cyclopentanecarboxylic acid, 1-amino-

Registry Number: 52-52-8

Descriptor UI: D003515

Alternative terms: Cycloleucine; 1-Aminocyclopentanecarboxylic Acid; 1 Aminocyclopentanecarboxylic Acid; Acid, 1-Aminocyclopentanecarboxylic; Aminocyclopentanecarboxylic Acid; Acid, Aminocyclopentanecarboxylic; NSC 1026; 1026, NSC;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.426.392.368.450.350; D12.125.072.170;

History Note: 91(75); was see under AMINO ACIDS 1975-90