Cyclopentanes - Pharmacokinetics
Research News and Information

Sunday, November 22, 2009

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

30 May 2009 Members of the aldo-keto reductase (AKR) superfamily, particularly the AKR1C subfamily, are emerging as important mediators of the pathology of cancer. Agents that inhibit these enzymes may provide novel agents for either the chemoprevention or ... Read more...

Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats.

9 Mar 2009 A single dose by gavage of bilobalide (30 mg/kg) was found to produce a time-dependent induction of hepatic cytochrome P450 (CYP) enzyme activity and protein expression in rats. An RT-PCR study further showed that mRNA expression of CYP2B was ... Read more...

Quantification of peramivir (a novel anti-influenza drug) in human plasma by hydrophilic interaction chromatography/tandem mass spectrometry.

22 Feb 2009 Peramivir is a novel influenza neuraminidase inhibitor. In this article, hydrophilic interaction chromatography coupled with tandem mass spectrometry was developed to determine peramivir in human plasma. The positive ion MRM mode was performed and ... Read more...

Latest indexed articles for 'Cyclopentanes - Pharmacokinetics'

These are the very latest articles for this heading:

• AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects. 30 May 2009
• Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. 9 Mar 2009
• Quantification of peramivir (a novel anti-influenza drug) in human plasma by hydrophilic interaction chromatography/tandem mass spectrometry. 22 Feb 2009
• Fragrance material review on cyclohexyl cyclopent-2-ene-1-acetate. 17 Sep 2008
• Tetrahydro anthranilic acid as a surrogate for anthranilic acid: application to the discovery of potent niacin receptor agonists. 29 Apr 2008
• Safety, efficacy and anti-inflammatory activity of rho iso-alpha-acids from hops. 18 Mar 2008
• A novel class of amino-alkylcyclohexanes as uncompetitive, fast, voltage-dependent, N-methyl-D-aspartate (NMDA) receptor antagonists--in vitro characterization. 29 Aug 2007
• Synthesis and evaluation of 4/5-hydroxy-2,3-diaryl(substituted)-cyclopent-2-en-1-ones as cis-restricted analogues of combretastatin A-4 as novel anticancer agents. 19 Mar 2007
• Extrapolating from animal studies to the efficacy in humans of a pretreatment combination against organophosphate poisoning. 27 Sep 2006
• 2-Acetyl-1,3-cyclopentanedione-oxovanadium(IV) complexes. Acidity and implications for gastrointestinal absorption. 10 Sep 2006
• Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers. 3 Dec 2005
• Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors. 27 Feb 2005
• Proliferation-dependent changes in amino acid transport and glucose metabolism in glioma cell lines. 27 Feb 2005
• Proliferation-dependent changes in amino acid transport and glucose metabolism in glioma cell lines. 11 May 2004
• Subacute toxicity and toxicokinetics of CJ-10882, a type IV phosphodiesterase inhibitor, after 4-week repeated oral administration in dogs. 28 Feb 2004
• Muscarinic M(3) receptor antagonists with (2R)-2-[(1R)-3,3-difluorocyclopentyl]-2-hydroxyphenylacetamide Structures. Part 2. 5 Jul 2003
• Selective delivery of CB300638, a cyclopenta[g]quinazoline-based thymidylate synthase inhibitor into human tumor cell lines overexpressing the alpha-isoform of the folate receptor. 29 Jun 2003
• Pharmacokinetics of Ginkgo biloba extracts. 30 May 2003
• Oral administration of cyclopentane neuraminidase inhibitors protects ferrets against influenza virus infection. 30 Mar 2002
• Population analysis of the pharmacokinetics and pharmacodynamics of RWJ-270201 (BCX-1812) in treating experimental influenza A and B virus in healthy volunteers. 30 Dec 2001

See a longer list of these articles.

Technical information about 'Cyclopentanes'

Definition: A group of alicyclic hydrocarbons with the general formula R-C5H9.

Registry Number: 0

Descriptor UI: D003517

Alternative terms: Cyclopentanes; Cyclopentadienes; Cyclopentane; Cyclopentenes;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.426.392.368.450;

History Note: 75; was CYCLOPENTANE 1966-74