Cytochrome P-450 Enzyme System - Drug effects
Research News and Information

Monday, November 23, 2009

Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.

29 Jun 2009 Azoles are the mainstay of oral therapy for aspergillosis. Azole resistance in Aspergillus has been reported infrequently. The first resistant isolate was detected in 1999 in Manchester, UK. In a clinical collection of 519 A. fumigatus isolates, the ... Read more...

Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla.

13 Jun 2009 The renal kallikrein-kinin system is involved in the control of the intrarenal circulation and arterial pressure but bradykinin (Bk) effects on perfusion of individual kidney zones have not been examined in detail. Effects of Bk infused into renal ... Read more...

Retinoic acid 4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne.

11 Jun 2009 BACKGROUND: The cytochrome P450 (CYP) enzyme CYP26 (retinoic acid [RA] 4-hydroxylase) initiates the catabolism of all-trans RA (tRA) and limits the effects of tRA. The CYP26 enzyme acts specifically on tRA, but not 13-cis RA (isotretinoin), a ... Read more...

Latest indexed articles for 'Cytochrome P-450 Enzyme System - Drug effects'

These are the very latest articles for this heading:

• Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure. 29 Jun 2009
• Do the association of cytochrome P450 interacting drugs, influence clopidogrel efficacity? 29 Jun 2009
• Differential action of bradykinin on intrarenal regional perfusion in the rat: waning effect in the cortex and major impact in the medulla. 13 Jun 2009
• Retinoic acid 4-hydroxylase inducibility and clinical response to isotretinoin in patients with acne. 11 Jun 2009
• [Clinically relevant drug interactions with new generation antidepressants and antipsychotics] 30 May 2009
• Study on the pharmacokinetics drug-drug interaction potential of Glycyrrhiza uralensis, a traditional Chinese medicine, with lidocaine in rats. 29 Apr 2009
• Enhanced hepatic and kidney cytochrome p-450 activities in nandrolone decanoate treated albino mice. 30 Mar 2009
• Proton pump inhibitors and clopidogrel - hazardous drug interaction or hazardous interpretation of data? 30 Mar 2009
• A simplified method to determine five cytochrome p450 probe drugs by HPLC in a single run. 30 Mar 2009
• Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats. 9 Mar 2009
• Updates on cytochrome P450-mediated cardiovascular drug interactions. 27 Feb 2009
• [Statin therapy and muscle disorders] 6 Feb 2009
• Induction of multiple drug transporters by efavirenz. 30 Jan 2009
• Identification and exploration of herb-drug combinations used by cancer patients. 25 Jan 2009
• Characterization of human cytochrome P450 enzymes involved in the biotransformation of eperisone. 30 Dec 2008
• Antiretroviral and statin drug-drug interactions. 30 Dec 2008
• Ritonavir greatly impairs CYP3A activity in HIV infection with chronic viral hepatitis. 29 Nov 2008
• Clinical characteristics of patients with drug-induced QT interval prolongation and torsade de pointes: identification of risk factors. 22 Nov 2008
• Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. 19 Nov 2008
• Polyaspartoyl.L-arginine enhances prostacyclin synthesis in rat aortic endothelial cells. 9 Nov 2008

See a longer list of these articles.

Technical information about 'Cytochrome P-450 Enzyme System'

Definition: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

Chemical name: Cytochrome P 450

Registry Number: 9035-51-2

Descriptor UI: D003577

Alternative terms: Cytochrome P-450 Enzyme System; Cytochrome P 450 Enzyme System; Cytochrome P-450; Cytochrome P 450; Cytochrome P450; Cytochrome P-450 Monooxygenase; Cytochrome P 450 Monooxygenase; Monooxygenase, Cytochrome P-450; Cytochrome P-450-Dependent Monooxygenase; Cytochrome P 450 Dependent Monooxygenase; Monooxygenase, Cytochrome P-450-Dependent; Cytochrome P-450 Oxygenase; Cytochrome P 450 Oxygenase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.244.453; D08.811.682.690.708.170; D12.776.422.220.453;

History Note: 73; CYTOCHROME P-450 OXYGENASE was NM 1977-96

Technical Notes: GEN or unspecified; prefer specific cytochrome P-450's; /biosyn /physiol permitted