Cytochrome P-450 Enzyme System - Metabolism
Research News and Information

Monday, November 23, 2009

Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices.

13 Oct 2009 We describe an in situ fluorescence optical detection system to demonstrate real-time and non-invasive detection of reaction products in a microfluidic device while under perfusion within a standard incubator. The detection system is designed to be ... Read more...

QSAR of cytochrome inhibitors.

29 Sep 2009 Cytochrome P450 (CYP450) enzymes are predominantly involved in the Phase I metabolism of xenobiotics. Metabolic inhibition and induction can give rise to clinically important drug-drug interactions. Metabolic stability is a prerequisite for ... Read more...

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos.

29 Sep 2009 Hox and Cdx transcription factors regulate embryonic positional identities. Cdx mutant mice display posterior body truncations of the axial skeleton, neuraxis, and caudal urorectal structures. We show that trunk Hox genes stimulate axial extension, ... Read more...

Latest indexed articles for 'Cytochrome P-450 Enzyme System - Metabolism'

These are the very latest articles for this heading:

• Fluorescence optical detection in situ for real-time monitoring of cytochrome P450 enzymatic activity of liver cells in multiple microfluidic devices. 13 Oct 2009
• QSAR of cytochrome inhibitors. 29 Sep 2009
• Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. 29 Sep 2009
• Kinetics and activation parameters for oxidations of styrene by Compounds I from the cytochrome P450(BM-3) (CYP102A1) heme domain and from CYP119. 27 Sep 2009
• Evolution of a novel phenolic pathway for pollen development. 23 Sep 2009
• Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice. 18 Sep 2009
• Synergistic increases of metabolism and oxidation-reduction genes on their expression after combined treatment with a CYP1A inducer and andrographolide. 4 Sep 2009
• Prediction of human cytochrome P450 2B6-substrate interactions using hierarchical support vector regression approach. 30 Aug 2009
• Flavin-containing monooxygenase 1-catalysed N,N-dimethylamphetamine N-oxidation. 30 Aug 2009
• Prediction of Phase I single-dose pharmacokinetics using recombinant cytochromes P450 and physiologically based modelling. 30 Aug 2009
• Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate? 30 Aug 2009
• Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance. 29 Aug 2009
• Risk of combining PPIs with thienopyridines: fact or fiction? 29 Aug 2009
• In vitro characterization of Synechocystis CYP120A1 revealed the first nonanimal retinoic acid hydroxylase. 22 Aug 2009
• The gene road to royalty--differential expression of hydroxylating genes in the mandibular glands of the honeybee. 19 Aug 2009
• The 1.5-A structure of XplA-heme, an unusual cytochrome P450 heme domain that catalyzes reductive biotransformation of royal demolition explosive. 17 Aug 2009
• miRNA regulation through ligand occupancy of a nuclear hormone receptor. 16 Aug 2009
• Aryl hydrocarbon receptor activation and overexpression upregulated fibroblast growth factor-9 in human lung adenocarcinomas. 13 Aug 2009
• Ecotoxicological multilevel-evaluation of the effects of fenbendazole exposure to Chironomus riparius larvae. 12 Aug 2009
• Determination of stereoselective interaction between enantiomers of chiral gamma-aryl-1H-1,2,4-triazole derivatives and Penicillium digitatum. 10 Aug 2009

See a longer list of these articles.

Technical information about 'Cytochrome P-450 Enzyme System'

Definition: A superfamily of hundreds of closely related HEMEPROTEINS found throughout the phylogenetic spectrum, from animals, plants, fungi, to bacteria. They include numerous complex monooxygenases (MIXED FUNCTION OXYGENASES). In animals, these P-450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs (BIOTRANSFORMATION). They are classified, according to their sequence similarities rather than functions, into CYP gene families (>40% homology) and subfamilies (>59% homology). For example, enzymes from the CYP1, CYP2, and CYP3 gene families are responsible for most drug metabolism.

Chemical name: Cytochrome P 450

Registry Number: 9035-51-2

Descriptor UI: D003577

Alternative terms: Cytochrome P-450 Enzyme System; Cytochrome P 450 Enzyme System; Cytochrome P-450; Cytochrome P 450; Cytochrome P450; Cytochrome P-450 Monooxygenase; Cytochrome P 450 Monooxygenase; Monooxygenase, Cytochrome P-450; Cytochrome P-450-Dependent Monooxygenase; Cytochrome P 450 Dependent Monooxygenase; Monooxygenase, Cytochrome P-450-Dependent; Cytochrome P-450 Oxygenase; Cytochrome P 450 Oxygenase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.244.453; D08.811.682.690.708.170; D12.776.422.220.453;

History Note: 73; CYTOCHROME P-450 OXYGENASE was NM 1977-96

Technical Notes: GEN or unspecified; prefer specific cytochrome P-450's; /biosyn /physiol permitted