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Cytotoxicity, Immunologic - Physiology
Research News and Information
Definition of 'Cytotoxicity, Immunologic'The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement. Common names: Cytotoxicity, Immunologic; Immunologic Cytotoxicity; Immunologic Tumoricidal Activities; Tumoricidal Activities, Immunologic; Tumoricidal Activity, Immunologic; Immunologic Tumoricidal Activity |
Sunday, November 22, 2009
The developmental role of natural killer cells at the fetal-maternal interface.
29 Sep 2009 
Natural killer (NK) cells have been extensively studied in their traditional roles in host defense against tumor or virally infected cells. Uterine NK cells are of 2 distinct subsets: endometrial NK (eNK) cells, found in the uterus during the ... Read more...
Migratory and antigen presentation functions of IFN-producing killer dendritic cells.
2 Aug 2009 The CD11c(int) B220(+) NK1.1(+) CD49(+) subset of cells has recently been described as IFN-producing killer dendritic cells (IKDC), which share phenotypic and functional properties with both dendritic cells and natural killer cells. We have ... Read more...
Antigen presented by tumors in vivo determines the nature of CD8+ T-cell cytotoxicity.
2 Aug 2009 The biological relevance of the perforin and Fas ligand (FasL) cytolytic pathways of CD8(+) T lymphocytes (CTL) for cancer immunotherapy is controversial. We investigated the importance of these pathways in a murine renal cell carcinoma expressing ... Read more...
Latest indexed articles for 'Cytotoxicity, Immunologic - Physiology'
These are the very latest articles for this heading:
- The developmental role of natural killer cells at the fetal-maternal interface. 29 Sep 2009
- Migratory and antigen presentation functions of IFN-producing killer dendritic cells. 2 Aug 2009
- Antigen presented by tumors in vivo determines the nature of CD8+ T-cell cytotoxicity. 2 Aug 2009
- Il-21 enhances NK cell activation and cytolytic activity and induces Th17 cell differentiation in inflammatory bowel disease. 30 Jul 2009
- Immune-mediated antitumor activity of reovirus is required for therapy and is independent of direct viral oncolysis and replication. 7 Jun 2009
- Impaired differentiation and cytotoxicity of natural killer cells in systemic lupus erythematosus. 30 May 2009
- Functional role of human NK cell receptor 2B4 (CD244) isoforms. 30 May 2009
- Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the alpha2 domain. 30 May 2009
- CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells. 12 May 2009
- Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. 5 May 2009
- PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model. 3 May 2009
- Ignition of p53 bomb sensitizes tumor cells to granzyme K-mediated cytolysis. 13 Feb 2009
- Lipid rafts uncouple surface expression of transmembrane TNF-alpha from its cytotoxicity associated with ICAM-1 clustering in Raji cells. 6 Feb 2009
- Optical imaging of cellular immunotherapy against prostate cancer. 30 Dec 2008
- Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells. 16 Nov 2008
- Immuno-modulatory effects of relaxation training and guided imagery in women with locally advanced breast cancer undergoing multimodality therapy: a randomised controlled trial. 10 Nov 2008
- The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases. 3 Nov 2008
- TLR2-dependent eosinophil interactions with mycobacteria: role of alpha-defensins. 29 Oct 2008
- The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. 28 Oct 2008
- Low natural killer cell cytotoxic activity in autism: the role of glutathione, IL-2 and IL-15. 14 Oct 2008
See a longer list of these articles.
Technical information about 'Cytotoxicity, Immunologic'
Definition: The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Descriptor UI: D003602
Alternative terms: Cytotoxicity, Immunologic; Immunologic Cytotoxicity; Immunologic Tumoricidal Activities; Tumoricidal Activities, Immunologic; Tumoricidal Activity, Immunologic; Immunologic Tumoricidal Activity;
Related Mesh Headings: Killer Cells, Natural; T-Lymphocytes, Cytotoxic; Complement Membrane Attack Complex; Killer Cells, Lymphokine-Activated; Antibodies, Bispecific;
Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects; ethics;
Tree Number: G12.425.270;
History Note: 78
Technical Notes: note category: reserve for process: do not confuse with CYTOTOXICITY TESTS, IMMUNOLOGIC; DF: CYTOTOX IMMUNOL