D-Amino-Acid Oxidase
Research News and Information

Sunday, November 22, 2009

Isocitrate lyase supplies precursors for hydrogen cyanide production in a cystic fibrosis isolate of Pseudomonas aeruginosa.

19 Aug 2009 Pseudomonas aeruginosa colonizes and can persist in the lungs of cystic fibrosis (CF) patients for decades. Adaptation of P. aeruginosa to the CF lung environment causes various genotypic and phenotypic alterations in the bacterium that facilitate ... Read more...

Optimization of D-amino acid oxidase for low substrate concentrations--towards a cancer enzyme therapy.

2 Aug 2009 D-amino acid oxidase (DAAO) has recently become of interest as a biocatalyst for industrial applications and for therapeutic treatments. It has been used in gene-directed enzyme prodrug therapies, in which its production of H2O2 in tumor cells can ... Read more...

Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges.

6 Jul 2009 Antipsychotics, the drugs used currently for the treatment of schizophrenia, produce their therapeutic effects via the blockade of dopamine receptors. These compounds are, however, limited in their therapeutic efficacy and have side effect ... Read more...

Latest indexed articles for 'D-Amino-Acid Oxidase'

These are the very latest articles for this heading:

• Isocitrate lyase supplies precursors for hydrogen cyanide production in a cystic fibrosis isolate of Pseudomonas aeruginosa. 19 Aug 2009
• Optimization of D-amino acid oxidase for low substrate concentrations--towards a cancer enzyme therapy. 2 Aug 2009
• Commentary: genome-based CNS drug discovery: D-amino acid oxidase (DAAO) as a novel target for antipsychotic medications: progress and challenges. 6 Jul 2009
• Reactive oxygen species and peroxisomes: struggling for balance. 29 Jun 2009
• Chiral ligand-exchange CE assays for separation of amino acid enantiomers and determination of enzyme kinetic constant. 29 Jun 2009
• [Discovery of D-serine dehydratase in vertebrate and its deficiency in mammals] 29 Jun 2009
• Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection. 21 Jun 2009
• Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. 9 Jun 2009
• DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. 10 May 2009
• Alteration of kynurenic acid concentration in rat plasma following optically pure kynurenine administration: a comparative study between enantiomers. 30 Mar 2009
• Relevance of weak flavin binding in human D-amino acid oxidase. 30 Mar 2009
• Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia. 12 Feb 2009
• Establishment of a cryopreservation method for the industrial use of D-amino acid oxidase-overexpressing Escherichia coli. 5 Feb 2009
• Molecular cloning and expression in Escherichia coli of an active fused Zea mays L. D-amino acid oxidase. 30 Jan 2009
• Simple and rapid genotyping of D-amino acid oxidase gene recognizing a crucial variant in the ddY strain using microchip electrophoresis. 30 Jan 2009
• Interaction of D-amino acid oxidase with carbon nanotubes: implications in the design of biosensors. 30 Jan 2009
• Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice. 28 Dec 2008
• The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. 14 Dec 2008
• Investigation of G72 (DAOA) expression in the human brain. 9 Dec 2008
• Stabilization of D-amino acid oxidase from Rhodosporidium toruloides by immobilization onto magnetic nanoparticles. 7 Dec 2008

See a longer list of these articles.

Technical information about 'D-Amino-Acid Oxidase'

Chemical name: D-Amino-acid:oxygen oxidoreductase (deaminating)

Registry Number: EC 1.4.3.3

Descriptor UI: D003605

Alternative terms: D-Amino-Acid Oxidase; D Amino Acid Oxidase; Oxidase, D-Amino-Acid; dextro-Amino Acid Oxidase; Acid Oxidase, dextro-Amino; Oxidase, dextro-Amino Acid; dextro Amino Acid Oxidase; D-Amino Acid Dehydrogenase; Acid Dehydrogenase, D-Amino; D Amino Acid Dehydrogenase; Dehydrogenase, D-Amino Acid;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Tree Number: D08.811.682.664.500.125;

Online Note: use D-AMINO-ACID OXIDASE to search D-AMINO ACID OXIDASE 1974-94 & D-AMINOACID OXIDASE 1966-73

History Note: 95; was D-AMINO ACID OXIDASE 1974-94, was D-AMINOACID OXIDASE 1963-73 (Prov 1963-65)