Dacarbazine - Analogs & derivatives
Research News and Information

Sunday, November 22, 2009

Alveolar rhabdomyosarcoma of the extremity and nodal metastasis: Is the in-transit lymphatic system at risk?

13 Dec 2009 Alveolar rhabdomyosarcoma (RMS) of the extremity is not infrequently associated with regional node metastasis. Knowledge of lymphatic drainage of extremity RMSs is important to determine radiotherapy fields. In this report we describe two patients ... Read more...

Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience.

29 Nov 2009 BACKGROUND: The prognosis for recurrent/progressive Ewing sarcoma (ES) remains poor. Pre-clinical, adult phase I and II trials have demonstrated the combination of irinotecan and temozolomide to have schedule-dependent synergy and significant ... Read more...

Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors.

29 Sep 2009 Insufficient response to oral temozolomide (TMZ) in children with brain tumor may depend on the repair-action of inducible O6-methylguanine-DNA methyltransferase (MGMT). To investigate the clinical relevance of MGMT expression, we analyzed MGMT ... Read more...

Latest indexed articles for 'Dacarbazine - Analogs & derivatives'

These are the very latest articles for this heading:

• Alveolar rhabdomyosarcoma of the extremity and nodal metastasis: Is the in-transit lymphatic system at risk? 13 Dec 2009
• Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience. 29 Nov 2009
• Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors. 29 Sep 2009
• Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity. 29 Sep 2009
• Non-Hodgkin lymphoma following temozolomide. 29 Sep 2009
• Recurrent PNET with MGMT methylation responds to temozolomide. 30 Aug 2009
• Population-based study of pseudoprogression after chemoradiotherapy in GBM. 30 Aug 2009
• A rare case of aplastic anemia caused by temozolomide. 30 Aug 2009
• Radiosensitizing effects of temozolomide observed in vivo only in a subset of O6-methylguanine-DNA methyltransferase methylated glioblastoma multiforme xenografts. 30 Aug 2009
• Two phase II trials of temozolomide with interferon-alpha2b (pegylated and non-pegylated) in patients with recurrent glioblastoma multiforme. 16 Aug 2009
• Temozolomide treatment of a pituitary carcinoma and two pituitary macroadenomas resistant to conventional therapy. 2 Aug 2009
• Perioperative high-dose-rate brachytherapy in the treatment of recurrent malignant gliomas. 2 Aug 2009
• [Recent trends in the pathophysiology and treatment of pituitary adenomas] 30 Jul 2009
• Nodular malignant melanoma and multiple cutaneous neoplasms under immunosuppression with azathioprine. 30 Jul 2009
• First experiences with low-dose anti-angiogenic treatment in gliomatosis cerebri with signs of angiogenic activity. 30 Jul 2009
• Methionine restriction reduces the chemosensitivity of central nervous system tumour cell lines. 30 Jul 2009
• A phase IB trial of intravenous INO-1001 plus oral temozolomide in subjects with unresectable stage-III or IV melanoma. 30 Jul 2009
• Temozolomide concomitant and adjuvant to radiotherapy in elderly patients with glioblastoma: correlation with MGMT promoter methylation status. 30 Jul 2009
• Overall survival of newly diagnosed glioblastoma patients receiving carmustine wafers followed by radiation and concurrent temozolomide plus rotational multiagent chemotherapy. 30 Jul 2009
• IgE, allergy, and risk of glioma: update from the San Francisco Bay Area Adult Glioma Study in the temozolomide era. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Dacarbazine'

Definition: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)

Chemical name: 1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-

Registry Number: 4342-03-4

Descriptor UI: D003606

Alternative terms: Dacarbazine; Decarbazine; DIC; Dimethyl Triazeno Imidazole Carboxamide; DTIC; ICDT; 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide; Dimethyl Imidazole Carboxamide; Carboxamide, Dimethyl Imidazole; Imidazole Carboxamide, Dimethyl; NSC-45388; NSC 45388; NSC45388; DTIC-Dome; DTIC Dome; DTICDome; Biocarbazine; Deticene;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Antineoplastic Agents, Alkylating;

Tree Number: D02.925.200; D03.383.129.308.240;

History Note: 80(75)