Dendritic Spines - Pathology
Research News and Information

Monday, November 23, 2009

Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring.

30 Aug 2009 Prenatal stress alters neuronal morphology of mesocorticolimbic structures such as frontal cortex and hippocampus in the adult offspring. We investigated here the effects of prenatal stress on the spine density and the dendrite morphology of ... Read more...

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

17 Aug 2009 Alzheimer's disease (AD) represents the most common age-related neurodegenerative disorder. It is characterized by the invariant accumulation of the beta-amyloid peptide (Abeta), which mediates synapse loss and cognitive impairment in AD. Current ... Read more...

Positive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression.

30 Jul 2009 Carlsson has put forward the hypothesis that the positive and negative symptoms of schizophrenia are due to failure of mesolimbic and mesocortical projections consequent on hypofunction of the glutamate N-methyl-d-aspartate (NMDA) receptor. The ... Read more...

Latest indexed articles for 'Dendritic Spines - Pathology'

These are the very latest articles for this heading:

• Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring. 30 Aug 2009
• Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. 17 Aug 2009
• Positive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression. 30 Jul 2009
• Thin, stubby or mushroom: spine pathology in Alzheimer's disease. 30 May 2009
• Partial kindling induces neurogenesis, activates astrocytes and alters synaptic morphology in the dentate gyrus of freely moving adult rats. 12 May 2009
• Dendritic spine pathologies in hippocampal pyramidal neurons from Rett syndrome brain and after expression of Rett-associated MECP2 mutations. 10 May 2009
• The "Down syndrome critical region" is sufficient in the mouse model to confer behavioral, neurophysiological, and synaptic phenotypes characteristic of Down syndrome. 4 May 2009
• Lower diffusion in white matter of children with prenatal methamphetamine exposure. 13 Apr 2009
• Environmental enrichment restores memory functioning in mice with impaired IL-1 signaling via reinstatement of long-term potentiation and spine size enlargement. 16 Mar 2009
• Dendritic pathology in Alzheimer's disease. 15 Mar 2009
• Altered dendritic spine plasticity in cocaine-withdrawn rats. 2 Mar 2009
• Neurochemistry, neuropathology, and heredity in SAMP8: a mouse model of senescence. 25 Feb 2009
• Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. 22 Feb 2009
• Thick visual cortex in the early blind. 16 Feb 2009
• Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease. 16 Feb 2009
• Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. 30 Jan 2009
• Persistent working memory dysfunction following traumatic brain injury: evidence for a time-dependent mechanism. 2009
• Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory. 29 Nov 2008
• Two-photon imaging during prolonged middle cerebral artery occlusion in mice reveals recovery of dendritic structure after reperfusion. 10 Nov 2008
• Stressful experience has opposite effects on dendritic spines in the hippocampus of cycling versus masculinized females. 20 Oct 2008

See a longer list of these articles.

Technical information about 'Dendritic Spines'

Definition: Spiny processes on DENDRITES, each of which receives excitatory input from one nerve ending (NERVE ENDINGS). They are commonly found on PURKINJE CELLS and PYRAMIDAL CELLS.

Descriptor UI: D049229

Alternative terms: Dendritic Spines; Dendritic Spine; Spine, Dendritic; Spines, Dendritic;

Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; ultrastructure; ultrasonography; chemistry; virology; genetics;

Tree Number: A08.663.256.200; A11.284.180.225.169; A11.671.240.169;

History Note: 2005