Dendritic Spines
Research News and Information

Saturday, November 21, 2009

Angelman syndrome: current understanding and research prospects.

30 Oct 2009 Angelman syndrome is a neurogenetic disorder characterized by developmental delay, severe intellectual disability, absent speech, exuberant behavior with happy demeanor, motor impairment, and epilepsy, due to deficient UBE3A gene expression that may ... Read more...

Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity.

12 Oct 2009 Estrogen, in addition to its genomic effects in brain, causes rapid and reversible changes to synaptic operations. We report here that these acute actions are due to selective activation of an actin-signaling cascade normally used in the production ... Read more...

Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking.

12 Oct 2009 The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that organizes and stabilizes receptors, ion channels, structural, and signaling proteins necessary for synaptic function. To study the stabilization of proteins ... Read more...

Latest indexed articles for 'Dendritic Spines'

These are the very latest articles for this heading:

• Angelman syndrome: current understanding and research prospects. 30 Oct 2009
• EphB maintains dendritic spine morphology through focal adhesion kinase. 19 Oct 2009
• Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. 12 Oct 2009
• Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. 12 Oct 2009
• Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines. 4 Sep 2009
• Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons. 30 Aug 2009
• Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease. 30 Aug 2009
• Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring. 30 Aug 2009
• The W cell pathway to cat primary visual cortex. 30 Aug 2009
• Diacylglycerol kinase beta promotes dendritic outgrowth and spine maturation in developing hippocampal neurons. 17 Aug 2009
• Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. 17 Aug 2009
• Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer's disease. 10 Aug 2009
• Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction. 10 Aug 2009
• Behaviorally evoked transient reorganization of hippocampal spines. 8 Aug 2009
• Postischemic PKC activation rescues retrograde and anterograde long-term memory. 8 Aug 2009
• Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration. 7 Aug 2009
• Distribution of D1 and D5 dopamine receptors in the primate and rat basolateral amygdala. 6 Aug 2009
• Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis. 3 Aug 2009
• Functional coupling between mGluR1 and Cav3.1 T-type calcium channels contributes to parallel fiber-induced fast calcium signaling within Purkinje cell dendritic spines. 3 Aug 2009
• Positive and negative symptoms in schizophrenia: the NMDA receptor hypofunction hypothesis, neuregulin/ErbB4 and synapse regression. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Dendritic Spines'

Definition: Spiny processes on DENDRITES, each of which receives excitatory input from one nerve ending (NERVE ENDINGS). They are commonly found on PURKINJE CELLS and PYRAMIDAL CELLS.

Descriptor UI: D049229

Alternative terms: Dendritic Spines; Dendritic Spine; Spine, Dendritic; Spines, Dendritic;

Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; ultrastructure; ultrasonography; chemistry; virology; genetics;

Tree Number: A08.663.256.200; A11.284.180.225.169; A11.671.240.169;

History Note: 2005