Dengue - Immunology
Research News and Information

Monday, March 15, 2010

Phase 1 trial of the dengue virus type 4 vaccine candidate rDEN4{Delta}30-4995 in healthy adult volunteers.

30 Oct 2009 rDEN4Delta30-4995 is a live attenuated dengue virus type 4 (DENV4) vaccine candidate specifically designed as a further attenuated derivative of the rDEN4Delta30 parent virus. In a previous study, 5 of 20 vaccinees who received 10(5) plaque-forming ... Read more...

Progress towards a dengue vaccine.

30 Oct 2009 The spread of dengue virus throughout the tropics represents a major, rapidly growing public health problem with an estimated 2.5 billion people at risk of dengue fever and the life-threatening disease, severe dengue. A safe and effective vaccine ... Read more...

Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control.

29 Sep 2009 Monocytes and macrophages are target cells for dengue infection. Besides their potential role for virus replication, activated monocytes/macrophages produce cytokines that may be critical for dengue pathology. To study the in vivo role of monocytes ... Read more...

Latest indexed articles for 'Dengue - Immunology'

These are the very latest articles for this heading:

• Phase 1 trial of the dengue virus type 4 vaccine candidate rDEN4{Delta}30-4995 in healthy adult volunteers. 30 Oct 2009
• Progress towards a dengue vaccine. 30 Oct 2009
• Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control. 29 Sep 2009
• Changing patterns of dengue epidemiology and implications for clinical management and vaccines. 30 Aug 2009
• Antibodies determine virulence in dengue. 30 Aug 2009
• T lymphocyte responses to heterologous secondary dengue virus infections. 30 Aug 2009
• A mouse model for studying dengue virus pathogenesis and immune response. 30 Aug 2009
• Dengue serosurveillance in Kolkata, facing an epidemic in West Bengal, India. 30 Aug 2009
• An adenovirus type 5 (AdV5) vector encoding an envelope domain III-based tetravalent antigen elicits immune responses against all four dengue viruses in the presence of prior AdV5 immunity. 5 Aug 2009
• HLA class I and II polymorphisms in Mexican Mestizo patients with dengue fever. Aug 2009
• [Pathophysiological mechanisms of dengue fever: critical review of current concepts] 30 Jul 2009
• Characteristics of dengue virus-infected peripheral blood mononuclear cell death that correlates with the severity of illness. 30 Jul 2009
• Gene expression profiling of dengue infected human primary cells identifies secreted mediators in vivo. 30 Jul 2009
• Production and characterization of anti-dengue capsid antibodies suggesting the N terminus region covering the first 20 amino acids of dengue virus capsid protein is predominantly immunogenic in mice. 28 Jun 2009
• Phage-displayed antibody fragments recognizing dengue 3 and dengue 4 viruses as tools for viral serotyping in sera from infected individuals. 4 Jun 2009
• Cardif-mediated signaling controls the initial innate response to dengue virus in vivo. Jun 2009
• Cross-reactive memory CD4+ T cells alter the CD8+ T-cell response to heterologous secondary dengue virus infections in mice in a sequence-specific manner. 30 May 2009
• TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais. 13 May 2009
• Acute arthropathy in patients with rash diseases: a comparative study. 3 May 2009
• Increased phagocytosis of platelets from patients with secondary dengue virus infection by human macrophages. 29 Apr 2009

See a longer list of these articles.

Technical information about 'Dengue'

Definition: An acute infectious, eruptive, febrile disease caused by four antigenically related but distinct serotypes of the DENGUE VIRUS. It is transmitted by the bite of infected Aedes mosquitoes, especially A. aegypti. Classical dengue (dengue fever) is self-limiting and characterized by fever, myalgia, headache, and rash. DENGUE HEMORRHAGIC FEVER is a more virulent form of dengue virus infection and a separate clinical entity. (From Dorland, 28th ed)

Descriptor UI: D003715

Alternative terms: Dengue; Dengue Fever; Fever, Dengue;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; transmission; urine; veterinary; ultrasonography; virology;

Tree Number: C02.081.270; C02.782.350.250.214; C02.782.417.214;

Technical Notes: a hemorrhagic fever caused by a flavivirus but note DENGUE HEMORRHAGIC FEVER