Diabetes Mellitus, Experimental - Physiopathology
Research News and Information

Sunday, November 22, 2009

Acute exercise reduces insulin resistance-induced TRB3 expression and amelioration of the hepatic production of glucose in the liver of diabetic mice.

29 Sep 2009 TRB3 (a mammalian homolog of Drosophila) is emerging as an important player in the regulation of insulin signaling. TRB3 can directly bind to Ser/Thr protein kinase Akt, the major downstream kinase of insulin signaling. Conversely, physical exercise ... Read more...

Proinsulin C-peptide reduces diabetes-induced glomerular hyperfiltration via efferent arteriole dilation and inhibition of tubular sodium reabsorption.

7 Sep 2009 C-peptide reduces diabetes-induced glomerular hyperfiltration in diabetic patients and experimental animal models. However, the mechanisms mediating the beneficial effect of C-peptide remain unclear. We investigated whether altered renal ... Read more...

Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats.

26 Aug 2009 In diabetic states, altered plasma insulin is likely to play key roles in 3-phosphoinositide-dependent protein kinase (PDK)/Akt pathway activation, in insulin resistance and in endothelial dysfunction. Since the molecular mechanism(s) remains ... Read more...

Latest indexed articles for 'Diabetes Mellitus, Experimental - Physiopathology'

These are the very latest articles for this heading:

• Acute exercise reduces insulin resistance-induced TRB3 expression and amelioration of the hepatic production of glucose in the liver of diabetic mice. 29 Sep 2009
• Proinsulin C-peptide reduces diabetes-induced glomerular hyperfiltration via efferent arteriole dilation and inhibition of tubular sodium reabsorption. 7 Sep 2009
• Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats. 26 Aug 2009
• Comparative study of regenerative potential of beta cells from young and aged donor mice using a novel islet transplantation model. 25 Aug 2009
• Interval training normalizes cardiomyocyte function, diastolic Ca2+ control, and SR Ca2+ release synchronicity in a mouse model of diabetic cardiomyopathy. 11 Aug 2009
• Functional magnetic resonance imaging of the spinal cord during sensory stimulation in diabetic rats. 30 Jul 2009
• Repetitive 50 Hz pulsed electromagnetic field ameliorates the diabetes-induced impairments in the relaxation response of rat thoracic aorta rings. 30 Jul 2009
• Dimethylthiourea normalizes velocity-dependent, but not force-dependent, index of ventricular performance in diabetic rats: role of myosin heavy chain isozyme. 22 Jul 2009
• Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography. 20 Jul 2009
• Generation of novel single-chain antibodies by phage-display technology to direct imaging agents highly selective to pancreatic beta- or alpha-cells in vivo. 8 Jul 2009
• Effect of the monocyte chemoattractant protein-1/CC chemokine receptor 2 system on nephrin expression in streptozotocin-treated mice and human cultured podocytes. 6 Jul 2009
• Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli. 4 Jul 2009
• Pyrrolidine dithiocarbamate reduces vascular prostanoid-induced responses in aged type 2 diabetic rat model. 29 Jun 2009
• Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. 29 Jun 2009
• Loss of intramuscular and submuscular interstitial cells of Cajal and associated enteric nerves is related to decreased gastric emptying in streptozotocin-induced diabetes. 28 Jun 2009
• Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein. 26 Jun 2009
• The protease inhibitor UCF-101 ameliorates streptozotocin-induced mouse cardiomyocyte contractile dysfunction in vitro: role of AMP-activated protein kinase. 24 Jun 2009
• Temporal changes in vascular reactivity in early diabetes mellitus in rats: role of changes in endothelial factors and in phosphodiesterase activity. 17 Jun 2009
• Recent advances in glucokinase activators for the treatment of type 2 diabetes. 7 Jun 2009
• Effects of grape seed proanthocyanidin extracts on aortic pulse wave velocity in streptozocin induced diabetic rats. 5 Jun 2009

See a longer list of these articles.

Technical information about 'Diabetes Mellitus, Experimental'

Definition: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.

Descriptor UI: D003921

Alternative terms: Diabetes Mellitus, Experimental; Experimental Diabetes Mellitus; Streptozotocin Diabetes; Diabetes, Streptozotocin; Streptozocin Diabetes; Diabete, Streptozocin; Diabetes, Streptozocin; Streptozocin Diabete; Alloxan Diabetes; Diabetes, Alloxan;

Related Mesh Headings: Mice, Inbred NOD;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; surgery; therapy; transmission; urine; ultrasonography; virology;

Tree Number: C18.452.394.750.074; C19.246.240; E05.598.500.374;

Online Note: use DIABETES MELLITUS, EXPERIMENTAL to search ALLOXAN DIABETES 1966-77

History Note: 78; ALLOXAN DIABETES was heading 1963-77

Technical Notes: index alloxan or streptozocin diabetes as DIABETES MELLITUS, EXPERIMENTAL (IM) + ALLOXAN or STREPTOZOCIN (NIM) only if the chem are particularly discussed; probably in animal so do not use /vet but don't forget check tag ANIMALS; DF: DIABETES MELLITUS EXPER