Diabetes Mellitus, Experimental
Research News and Information

Saturday, November 21, 2009

Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus.

30 Oct 2009 OBJECTIVE: To determine if topical application of naltrexone hydrochloride (NTX), an opioid antagonist, restores tear production and corneal sensation in rats with diabetes mellitus. METHODS: Type 1 diabetes was induced with streptozotocin in rats. ... Read more...

Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone.

10 Oct 2009 Type I diabetes mellitus is caused by autoimmune destruction of pancreatic beta cells, and effective treatment of the disease might require rescuing beta cell function in a context of reinstalled immune tolerance. Sertoli cells (SCs) are found in ... Read more...

Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice.

7 Oct 2009 Insulin deficiency in type 1 diabetes leads to disruptions in glucose, lipid, and ketone metabolism with resultant hyperglycemia, hyperlipidemia, and ketonemia. Exogenous insulin and hepatic insulin gene therapy cannot mimic the robust ... Read more...

Latest indexed articles for 'Diabetes Mellitus, Experimental'

These are the very latest articles for this heading:

• Dry eye reversal and corneal sensation restoration with topical naltrexone in diabetes mellitus. 30 Oct 2009
• Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone. 10 Oct 2009
• Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice. 7 Oct 2009
• Neuroprotective role of curcumin in the cerebellum of streptozotocin-induced diabetic rats. Oct 2009
• Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress. 29 Sep 2009
• Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in mice. 29 Sep 2009
• Thioredoxin interacting protein (TXNIP) induces inflammation through chromatin modification in retinal capillary endothelial cells under diabetic conditions. 29 Sep 2009
• Acute exercise reduces insulin resistance-induced TRB3 expression and amelioration of the hepatic production of glucose in the liver of diabetic mice. 29 Sep 2009
• Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. 25 Sep 2009
• Restoring erectile function by antioxidant therapy in diabetic rats. 15 Sep 2009
• Surface modification of islets with PEG-lipid for improvement of graft survival in intraportal transplantation. 13 Sep 2009
• Effects of diabetes mellitus, pressure-overload and their association on myocardial structure and function. 8 Sep 2009
• Mesangial cell-derived factors alter monocyte activation and function through inflammatory pathways: possible pathogenic role in diabetic nephropathy. 7 Sep 2009
• Proinsulin C-peptide reduces diabetes-induced glomerular hyperfiltration via efferent arteriole dilation and inhibition of tubular sodium reabsorption. 7 Sep 2009
• PKC-dependent superoxide production by the renal medullary thick ascending limb from diabetic rats. 7 Sep 2009
• Loss of arterial and renal nitric oxide bioavailability in hypertensive rats with diabetes: effect of beta-blockers. Sep 2009
• Ghrelin reverses experimental diabetic neuropathy in mice. Sep 2009
• Continuous buprenorphine delivery effect in streptozotocine-induced painful diabetic neuropathy in rats. 30 Aug 2009
• Stealth nanoparticles coated with heparin as peptide or protein carriers. 30 Aug 2009
• Topical atorvastatin in the treatment of diabetic wounds. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Diabetes Mellitus, Experimental'

Definition: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.

Descriptor UI: D003921

Alternative terms: Diabetes Mellitus, Experimental; Experimental Diabetes Mellitus; Streptozotocin Diabetes; Diabetes, Streptozotocin; Streptozocin Diabetes; Diabete, Streptozocin; Diabetes, Streptozocin; Streptozocin Diabete; Alloxan Diabetes; Diabetes, Alloxan;

Related Mesh Headings: Mice, Inbred NOD;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; surgery; therapy; transmission; urine; ultrasonography; virology;

Tree Number: C18.452.394.750.074; C19.246.240; E05.598.500.374;

Online Note: use DIABETES MELLITUS, EXPERIMENTAL to search ALLOXAN DIABETES 1966-77

History Note: 78; ALLOXAN DIABETES was heading 1963-77

Technical Notes: index alloxan or streptozocin diabetes as DIABETES MELLITUS, EXPERIMENTAL (IM) + ALLOXAN or STREPTOZOCIN (NIM) only if the chem are particularly discussed; probably in animal so do not use /vet but don't forget check tag ANIMALS; DF: DIABETES MELLITUS EXPER