 |
Diabetes Mellitus, Type 1 - Metabolism
Research News and Information
Definition of 'Diabetes Mellitus, Type 1'A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence. Common names: Diabetes Mellitus, Type 1; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Insulin Dependent; Insulin-Dependent Diabetes Mellitus; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Juvenile Onset; Juvenile-Onset Diabetes Mellitus; Type 1 Diabetes Mellitus |
Monday, November 23, 2009
7 Oct 2009 
Insulin deficiency in type 1 diabetes leads to disruptions in glucose, lipid, and ketone metabolism with resultant hyperglycemia, hyperlipidemia, and ketonemia. Exogenous insulin and hepatic insulin gene therapy cannot mimic the robust ... Read more...
T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event.
6 Oct 2009 Type 1 diabetes is a T cell-mediated autoimmune disease, characterized by lymphocytic infiltration of the pancreatic islets. It is currently thought that islet antigen specificity is not a requirement for islet entry and that diabetogenic T cells ... Read more...
6 Oct 2009 CD4(+)Foxp3(+) regulatory T cells (Treg cells) are known to control the progression of autoimmune diabetes, but when, where, and how they exert their influence in this context are questions still under vigorous debate. Exploiting a transgene ... Read more...
Latest indexed articles for 'Diabetes Mellitus, Type 1 - Metabolism'
These are the very latest articles for this heading:
- Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice. 7 Oct 2009
- T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. 6 Oct 2009
- How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. 6 Oct 2009
- Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. 25 Sep 2009
- Insulin teaches a new lesson in tolerance.
14 Sep 2009 - Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. 9 Sep 2009
- Reversing bacteria-induced vitamin D receptor dysfunction is key to autoimmune disease. 30 Aug 2009
- Generation of pluripotent stem cells from patients with type 1 diabetes. 29 Aug 2009
- Subcellular localization of Nox4 and regulation in diabetes. 15 Aug 2009
- Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. 8 Aug 2009
- Berberine differentially modulates the activities of ERK, p38 MAPK, and JNK to suppress Th17 and Th1 T cell differentiation in type 1 diabetic mice. 4 Aug 2009
- Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM). 2 Aug 2009
- Metabolic memory: implications for diabetic vascular complications. 30 Jul 2009
- The honeymoon phase: intersection of metabolism and immunology. 30 Jul 2009
- Remodeling rodent models to mimic human type 1 diabetes. 30 Jul 2009
- Protein expression in salivary glands of rats with streptozotocin diabetes. 30 Jul 2009
- Constitutive androstane receptor mediates the induction of drug metabolism in mouse models of type 1 diabetes. 30 Jul 2009
- Altered prefrontal glutamate-glutamine-gamma-aminobutyric acid levels and relation to low cognitive performance and depressive symptoms in type 1 diabetes mellitus. 30 Jul 2009
- Upregulation of myostatin gene expression in streptozotocin-induced type 1 diabetes mice is attenuated by insulin. 28 Jul 2009
- Reappraising the stereotypes of diabetes in the modern diabetogenic environment. 26 Jul 2009
See a longer list of these articles.
Technical information about 'Diabetes Mellitus, Type 1'
Definition: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Descriptor UI: D003922
Alternative terms: Diabetes Mellitus, Type 1; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Insulin Dependent; Insulin-Dependent Diabetes Mellitus; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Juvenile Onset; Juvenile-Onset Diabetes Mellitus; Type 1 Diabetes Mellitus; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Sudden Onset; Mellitus, Sudden-Onset Diabetes; Sudden-Onset Diabetes Mellitus; Diabetes Mellitus, Type I; IDDM; Diabetes Mellitus, Brittle; Brittle Diabetes Mellitus; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis Prone; Ketosis-Prone Diabetes Mellitus; Diabetes, Autoimmune; Autoimmune Diabete; Diabete, Autoimmune; Autoimmune Diabetes;
Related Mesh Headings: Mice, Inbred NOD;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C18.452.394.750.124; C19.246.267; C20.111.327;
History Note: 2005 (1984)
Technical Notes: MICE, INBRED NOD are a common model for this disease