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Diabetes Mellitus, Type 1 - Pathology
Research News and Information
Definition of 'Diabetes Mellitus, Type 1'A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence. Common names: Diabetes Mellitus, Type 1; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Insulin Dependent; Insulin-Dependent Diabetes Mellitus; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Juvenile Onset; Juvenile-Onset Diabetes Mellitus; Type 1 Diabetes Mellitus |
Sunday, November 22, 2009
6 Oct 2009 
CD4(+)Foxp3(+) regulatory T cells (Treg cells) are known to control the progression of autoimmune diabetes, but when, where, and how they exert their influence in this context are questions still under vigorous debate. Exploiting a transgene ... Read more...
CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice.
29 Sep 2009 CD8(+) T cells play a key role in the initiation of insulitis. However, the site(s) where naive CD8(+) T cells encounter beta-cell antigens and the mechanism(s) by which beta-cell autoimmunity is initiated remain to be determined. In the current ... Read more...
Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination.
12 Sep 2009 Tissue-specific autoimmune diseases such as type 1 diabetes (T1D) are characterized by T cell-driven pathology. Administration of autoantigenic peptides provides a strategy to selectively target the pathogenic T cell response. Indeed, treatment with ... Read more...
Latest indexed articles for 'Diabetes Mellitus, Type 1 - Pathology'
These are the very latest articles for this heading:
- How punctual ablation of regulatory T cells unleashes an autoimmune lesion within the pancreatic islets. 6 Oct 2009
- CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. 29 Sep 2009
- Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination. 12 Sep 2009
- Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. 9 Sep 2009
- Stem cells and a cure for type 1 diabetes?
7 Sep 2009 - Autoimmunity triggers in the NOD mouse: a role for natural auto-antibody reactivities in type 1 diabetes. 30 Aug 2009
- The -174GG interleukin-6 genotype is protective from retinopathy and nephropathy in juvenile onset type 1 diabetes mellitus. 30 Aug 2009
- Generation of pluripotent stem cells from patients with type 1 diabetes. 29 Aug 2009
- Insulin is a stronger inducer of insulin resistance than hyperglycemia in mice with type 1 diabetes mellitus (T1DM). 2 Aug 2009
- The pancreas in human type 1 diabetes: providing new answers to age-old questions. 30 Jul 2009
- MRI in diabetes: first results. 30 Jul 2009
- Upregulation of myostatin gene expression in streptozotocin-induced type 1 diabetes mice is attenuated by insulin. 28 Jul 2009
- Enterovirus infection, CXC chemokine ligand 10 (CXCL10), and CXCR3 circuit: a mechanism of accelerated beta-cell failure in fulminant type 1 diabetes. 27 Jul 2009
- Transgenic expression of single-chain anti-CTLA-4 Fv on beta cells protects nonobese diabetic mice from autoimmune diabetes. 25 Jul 2009
- Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.
14 Jul 2009 - Motor unit number estimate as a predictor of motor dysfunction in an animal model of type 1 diabetes. 12 Jul 2009
- Functional brain connectivity and neurocognitive functioning in patients with long-standing type 1 diabetes with and without microvascular complications: a magnetoencephalography study. 5 Jul 2009
- Renal and retinal effects of enalapril and losartan in type 1 diabetes. 30 Jun 2009
- Glycation and lipid peroxidation in children and adolescents with type 1 diabetes mellitus with and without diabetic complications. 29 Jun 2009
- Radiologic case study: diabetic myonecrosis of the posterior compartments of both thighs. 29 Jun 2009
See a longer list of these articles.
Technical information about 'Diabetes Mellitus, Type 1'
Definition: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
Descriptor UI: D003922
Alternative terms: Diabetes Mellitus, Type 1; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Insulin Dependent; Insulin-Dependent Diabetes Mellitus; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Juvenile Onset; Juvenile-Onset Diabetes Mellitus; Type 1 Diabetes Mellitus; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Sudden Onset; Mellitus, Sudden-Onset Diabetes; Sudden-Onset Diabetes Mellitus; Diabetes Mellitus, Type I; IDDM; Diabetes Mellitus, Brittle; Brittle Diabetes Mellitus; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis Prone; Ketosis-Prone Diabetes Mellitus; Diabetes, Autoimmune; Autoimmune Diabete; Diabete, Autoimmune; Autoimmune Diabetes;
Related Mesh Headings: Mice, Inbred NOD;
Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;
Tree Number: C18.452.394.750.124; C19.246.267; C20.111.327;
History Note: 2005 (1984)
Technical Notes: MICE, INBRED NOD are a common model for this disease