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Diabetes Mellitus, Type 1
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Definition of 'Diabetes Mellitus, Type 1'

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Common names: Diabetes Mellitus, Type 1; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Insulin Dependent; Insulin-Dependent Diabetes Mellitus; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Juvenile Onset; Juvenile-Onset Diabetes Mellitus; Type 1 Diabetes Mellitus

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Saturday, November 07, 2009

A better future for children with type 1 diabetes: Review of the conclusions from the Diabetes Control and Complications Trial and the Epidemiology of Diabetes Interventions and Complications study.

29 Sep 2009 Research shows a causal association between hyperglycemia and diabetic complications which include nephropathy, neuropathy, retinopathy and blood vessel and heart disease. Intensive control of blood glucose in children has been debated for years. ... Read more...


Diabetic microangiopathy in the liver: an autopsy study of incidence and association with other diabetic complications.

29 Sep 2009 Diabetic hepatosclerosis (DH) is a recently described form of diabetic microangiopathy with hepatic sinusoidal fibrosis and basement membrane deposition without cirrhosis. The objective was to investigate the frequency of DH and its correlation with ... Read more...


The human insulin gene is part of a large open chromatin domain specific for human islets.

26 Sep 2009 Knowledge of how insulin (INS) gene expression is regulated will lead to better understanding of normal and abnormal pancreatic beta cell function. We have mapped histone modifications over the INS region, coupled with an expression profile, in ... Read more...

 

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Technical information about 'Diabetes Mellitus, Type 1'

Definition: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

Descriptor UI: D003922

Alternative terms: Diabetes Mellitus, Type 1; Diabetes Mellitus, Insulin-Dependent; Diabetes Mellitus, Insulin Dependent; Insulin-Dependent Diabetes Mellitus; Diabetes Mellitus, Juvenile-Onset; Diabetes Mellitus, Juvenile Onset; Juvenile-Onset Diabetes Mellitus; Type 1 Diabetes Mellitus; Diabetes Mellitus, Sudden-Onset; Diabetes Mellitus, Sudden Onset; Mellitus, Sudden-Onset Diabetes; Sudden-Onset Diabetes Mellitus; Diabetes Mellitus, Type I; IDDM; Diabetes Mellitus, Brittle; Brittle Diabetes Mellitus; Diabetes Mellitus, Ketosis-Prone; Diabetes Mellitus, Ketosis Prone; Ketosis-Prone Diabetes Mellitus; Diabetes, Autoimmune; Autoimmune Diabete; Diabete, Autoimmune; Autoimmune Diabetes;

Related Mesh Headings: Mice, Inbred NOD;

Allowable Qualifiers: blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics; embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology;

Tree Number: C18.452.394.750.124; C19.246.267; C20.111.327;

History Note: 2005 (1984)

Technical Notes: MICE, INBRED NOD are a common model for this disease

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