Diazepam - Pharmacology
Research News and Information

Sunday, November 22, 2009

Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.

19 Oct 2009 Homeostatic regulation of synaptic strength in response to persistent changes of neuronal activity plays an important role in maintaining the overall level of circuit activity within a normal range. Absence of miniature EPSCs (mEPSCs) for a few ... Read more...

Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome.

30 Jul 2009 OBJECTIVE: The mechanisms of epileptogenesis in Sturge-Weber syndrome (SWS) are unknown. We explored the properties of neurons from human pediatric SWS cortex in vitro and tested in particular whether gamma-aminobutyric acid (GABA) excites neurons ... Read more...

Acute effect of Copaifera reticulata Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis.

30 Jul 2009 OBJECTIVES: Copaiba oil oleoresin exuded from Copaifera reticulata Ducke (CRD) is commonly used in anti-inflammatory, healing and anti-tumoral folk medicines. The purpose of this study was to investigate the putative anxiolytic effect of acute ... Read more...

Latest indexed articles for 'Diazepam - Pharmacology'

These are the very latest articles for this heading:

• Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. 19 Oct 2009
• Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome. 30 Jul 2009
• Acute effect of Copaifera reticulata Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis. 30 Jul 2009
• Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors. 2 Jul 2009
• Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice. 25 Jun 2009
• Central action of Araucaria angustifolia seed lectin in mice. 11 Jun 2009
• The effect of repeated diazepam administration on myocardial function in the ischemia-reperfused isolated rat heart. 30 May 2009
• 5-HT1A receptor activation is necessary for 5-MeODMT-dependent potentiation of feeding inhibition. 29 May 2009
• Impairment of the cortical GABAergic inhibitory system in catatonic stupor: a case report with neuroimaging. 27 May 2009
• An electro-encephalogram beta gap after induction with diazepam: a localization method in epileptogenic lesions. 20 May 2009
• Anxiolytic-like effects and safety profile of a tryptic hydrolysate from bovine alpha s1-casein in rats. 5 May 2009
• Humans and natural predators induce different fear/anxiety reactions and response pattern to diazepam in marmoset monkeys. May 2009
• A novel operant conflict procedure using incrementing shock intensities to assess the anxiolytic and anxiogenic effects of drugs. 29 Apr 2009
• Cardiopulmonary effects of diazepam-ketamine-isoflurane or xylazine-ketamine-isoflurane during abdominal surgery in foals. 29 Apr 2009
• Co-regulation of ocular dominance plasticity and NMDA receptor subunit expression in glutamic acid decarboxylase-65 knock-out mice. 28 Apr 2009
• The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits. 25 Apr 2009
• Different phases of afterdischarge during rapid kindling procedure in mice. 14 Apr 2009
• Stress-induced hyperthermia and infection-induced fever: two of a kind? 14 Apr 2009
• Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus. Apr 2009
• Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Diazepam'

Definition: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589)

Chemical name: 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-

Registry Number: 439-14-5

Descriptor UI: D003975

Alternative terms: Diazepam; 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; Apaurin; Diazemuls; Stesolid; Relanium; Seduxen; Sibazon; Valium; Faustan;

Related Mesh Headings: Receptors, GABA-A;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Adjuvants, Anesthesia; Anticonvulsants; Antiemetics; Hypnotics and Sedatives; Muscle Relaxants, Central; Anti-Anxiety Agents; Anesthetics, Intravenous; GABA Modulators;

Tree Number: D03.438.079.080.070.216;

History Note: 65(63)