Diazepam
Research News and Information

Monday, November 23, 2009

Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities.

19 Oct 2009 Homeostatic regulation of synaptic strength in response to persistent changes of neuronal activity plays an important role in maintaining the overall level of circuit activity within a normal range. Absence of miniature EPSCs (mEPSCs) for a few ... Read more...

Development of the space-resolved solid-phase microextraction technique and its application to biological matrices.

30 Aug 2009 To facilitate rapid in situ analyte monitoring within heterogeneous samples, a space-resolved solid phase microextraction (SR-SPME) technique was developed that utilized miniaturized segmented fibers. Initially, a multilayered agarose gel was used ... Read more...

Statistical evaluation of influence of polymers concentration on disintegration time and diazepam release from quick-disintegrating rapid release tablet.

30 Aug 2009 This study describes the formulation of rapidly disintegrating, fast dissolving diazepam tablets intended for use in the oral cavity. The tablets were prepared by the conventional wet granulation method using solid dispersion of the drug with ... Read more...

Latest indexed articles for 'Diazepam'

These are the very latest articles for this heading:

• Endocannabinoid-dependent homeostatic regulation of inhibitory synapses by miniature excitatory synaptic activities. 19 Oct 2009
• Development of the space-resolved solid-phase microextraction technique and its application to biological matrices. 30 Aug 2009
• Statistical evaluation of influence of polymers concentration on disintegration time and diazepam release from quick-disintegrating rapid release tablet. 30 Aug 2009
• Gift of the glob--is it foolproof? 30 Aug 2009
• The impact of diazepam's discovery on the treatment and understanding of status epilepticus. 6 Aug 2009
• Toxicity in three dogs from accidental oral administration of a topical endectocide containing moxidectin and imidacloprid. 30 Jul 2009
• High-dose diazepam facilitates core cooling during cold saline infusion in healthy volunteers. 30 Jul 2009
• Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome. 30 Jul 2009
• Design of packed-fiber solid-phase extraction device for analysis of the drug and its metabolite in plasma. 30 Jul 2009
• A family with paroxysmal nonkinesigenic dyskinesia: genetic and treatment issues. 30 Jul 2009
• Acute effect of Copaifera reticulata Ducke copaiba oil in rats tested in the elevated plus-maze: an ethological analysis. 30 Jul 2009
• Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors. 2 Jul 2009
• No cross-reactions between tetrazepam and other benzodiazepines: a possible chemical explanation. 29 Jun 2009
• Plasma level of atropine after accidental ingestion of Atropa belladonna. 29 Jun 2009
• Serotonin syndrome following sibutramine poisoning in a child, with sequential quantification of sibutramine and its primary and secondary amine metabolites in plasma. 29 Jun 2009
• Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. 27 Jun 2009
• Anticonvulsant, anxiolytic, and sedative properties of the roots of Nauclea latifolia Smith in mice. 25 Jun 2009
• Central action of Araucaria angustifolia seed lectin in mice. 11 Jun 2009
• Improved functions of human hepatocytes on NH3 plasma-grafted PEEK-WC-PU membranes. 2 Jun 2009
• Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy. 30 May 2009

See a longer list of these articles.

Technical information about 'Diazepam'

Definition: A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589)

Chemical name: 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-1-methyl-5-phenyl-

Registry Number: 439-14-5

Descriptor UI: D003975

Alternative terms: Diazepam; 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; Apaurin; Diazemuls; Stesolid; Relanium; Seduxen; Sibazon; Valium; Faustan;

Related Mesh Headings: Receptors, GABA-A;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Adjuvants, Anesthesia; Anticonvulsants; Antiemetics; Hypnotics and Sedatives; Muscle Relaxants, Central; Anti-Anxiety Agents; Anesthetics, Intravenous; GABA Modulators;

Tree Number: D03.438.079.080.070.216;

History Note: 65(63)