Dibenzothiazepines - Pharmacology
Research News and Information

Sunday, November 22, 2009

Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats.

30 Jul 2009 OBJECTIVES AND METHODS: We have previously demonstrated that quetiapine (QTP) had antidepressant-like action by using the chronic mild stress (CMS) paradigm, an animal model of human depression. The aim of this study was to investigate the molecular ... Read more...

Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists.

7 Apr 2009 A novel class of CB1 inverse agonists was discovered. To efficiently establish structure-activity relationships (SARs), new synthetic methodologies amenable for parallel synthesis were developed. The compounds were evaluated in a mammalian ... Read more...

Increased grey matter densities in schizophrenia patients with negative symptoms after treatment with quetiapine: a voxel-based morphometry study.

30 Dec 2008 Among new-generation antipsychotics, quetiapine was found to be associated with a partial 'normalization' of reduced functional activation in prefrontal and temporal areas and studies conducted by our group found a clinical improvement in negative ... Read more...

Latest indexed articles for 'Dibenzothiazepines - Pharmacology'

These are the very latest articles for this heading:

• Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats. 30 Jul 2009
• Targeting cognition in schizophrenia research: from etiology to treatment. 30 May 2009
• Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists. 7 Apr 2009
• The effect of quetiapine on auditory P300 response in patients with schizoaffective disorder: preliminary study. 30 Dec 2008
• Increased grey matter densities in schizophrenia patients with negative symptoms after treatment with quetiapine: a voxel-based morphometry study. 30 Dec 2008
• Impact of haloperidol and quetiapine on the expression of genes encoding antioxidant enzymes in human neuroblastoma SH-SY5Y cells. 18 Dec 2008
• [Quetiapin in bipolar disorders] 29 Nov 2008
• Quetiapine augmentation in depressed patients with partial response to antidepressants. 29 Nov 2008
• Dosing quetiapine in drug-naive first-episode psychosis: a controlled, double-blind, randomized, single-center study investigating efficacy, tolerability, and safety of 200 mg/day vs. 400 mg/day of quetiapine fumarate in 141 patients aged 15 to 25 years. 16 Nov 2008
• Antipsychotic drugs modulate Arc expression in the rat brain. 20 Oct 2008
• Quetiapine alleviates the cuprizone-induced white matter pathology in the brain of C57BL/6 mouse. 17 Oct 2008
• Increased impulsivity and disrupted attention induced by repeated phencyclidine are not attenuated by chronic quetiapine treatment. 6 Sep 2008
• Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice. 30 Aug 2008
• Demonstration of an anti-oxidative stress mechanism of quetiapine: implications for the treatment of Alzheimer's disease. 29 Jun 2008
• Quetiapine decreases alcohol consumption, craving, and psychiatric symptoms in dually diagnosed alcoholics. 29 Jun 2008
• Weight change in Parkinson and Alzheimer patients taking atypical antipsychotic drugs. 14 Jun 2008
• Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane? 25 Apr 2008
• Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder. 6 Jan 2008
• Augmentation of antidepressants with atypical antipsychotics: a review of the current literature. 30 Dec 2007
• Proton magnetic resonance spectroscopy during initial treatment with antipsychotic medication in schizophrenia. 17 Dec 2007

See a longer list of these articles.

Technical information about 'Dibenzothiazepines'

Registry Number: 0

Descriptor UI: D003987

Alternative terms: Dibenzothiazepines;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.886.680.702.500; D03.494.276;

History Note: 68