Dinoprostone - Biosynthesis
Research News and Information

Monday, November 23, 2009

Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity.

25 Sep 2009 AIMS: Inducible cyclooxygenase (COX-2) has been implicated in the process of inflammation and carcinogenesis. Chamomile has long been used in traditional medicine for the treatment of inflammatory diseases. In this study we aimed to investigate ... Read more...

Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells.

20 Sep 2009 BACKGROUND: Melatonin reduces the development of breast cancer interfering with oestrogen-signalling pathways, and also inhibits aromatase activity and expression. Our objective was to study the promoters through which melatonin modifies aromatase ... Read more...

The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats.

30 Aug 2009 BACKGROUND: Peripheral inflammatory pain is associated with an upregulation of spinal cord COX-2 (cyclooxygenase-2), with a subsequent increase in central prostaglandin E2 (PGE2) levels associated with the development of hyperalgesia. In this study, ... Read more...

Latest indexed articles for 'Dinoprostone - Biosynthesis'

These are the very latest articles for this heading:

• Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. 25 Sep 2009
• Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells. 20 Sep 2009
• The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. 30 Aug 2009
• Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells. 26 Aug 2009
• Francisella tularensis induces ubiquitin-dependent major histocompatibility complex class II degradation in activated macrophages. 22 Aug 2009
• Green tea epigallocatechin-3-gallate inhibits microsomal prostaglandin E(2) synthase-1. 4 Aug 2009
• Protein hydrolysates from beta-conglycinin enriched soybean genotypes inhibit lipid accumulation and inflammation in vitro. 30 Jul 2009
• Polyphenol metabolites from colonic microbiota exert anti-inflammatory activity on different inflammation models. 30 Jul 2009
• Roots of Daphne gnidium L. inhibit cell proliferation and induce apoptosis in the human breast cancer cell line MCF-7. 30 Jul 2009
• Calorie restriction enhances T-cell-mediated immune response in adult overweight men and women. 26 Jul 2009
• HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells. 26 Jul 2009
• Efficacy and pharmacokinetics of intravitreal non-steroidal anti-inflammatory drugs for intraocular inflammation. 21 Jul 2009
• Anti-inflammatory activity of Flavokawain B from Alpinia pricei Hayata. 20 Jul 2009
• Macrolide antibiotics like azithromycin increase lipopolysaccharide-induced IL-8 production by human gingival fibroblasts. 20 Jul 2009
• Cholesterol-3-beta, 5-alpha, 6-beta-triol induced PI(3)K-Akt-eNOS-dependent cyclooxygenase-2 expression in endothelial cells. 14 Jul 2009
• Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome. 6 Jul 2009
• Prostaglandin E2 is activated by airway injury and regulates fibroblast cytoskeletal dynamics. 29 Jun 2009
• Diverging effects of cortistatin and somatostatin on the production and release of prostanoids from rat cortical microglia and astrocytes. 21 Jun 2009
• Peripheral lipopolysaccharide administration induces cytokine mRNA expression in the viscera and brain of fever-refractory mice lacking microsomal prostaglandin E synthase-1. 2 Jun 2009
• Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor. 31 May 2009

See a longer list of these articles.

Technical information about 'Dinoprostone'

Definition: The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.

Chemical name: Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-

Registry Number: 363-24-6

Descriptor UI: D015232

Alternative terms: Dinoprostone; PGE2 alpha; alpha, PGE2; PGE2alpha; Prostaglandin E2 alpha; E2 alpha, Prostaglandin; alpha, Prostaglandin E2; Prostaglandin E2alpha; E2alpha, Prostaglandin; PGE2; Prostaglandin E2; E2, Prostaglandin; Prepidil Gel; Gel, Prepidil; Prostenon;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Oxytocics;

Tree Number: D10.251.355.255.100.637.250.200; D10.251.355.255.550.250.200; D23.469.050.175.725.780.200;

History Note: 89

Technical Notes: do not confuse with DINOPROST; /biosyn /physiol permitted