Dinoprostone
Research News and Information

Monday, November 23, 2009

Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells.

29 Nov 2009 Overexpression of cyclooxygenase-2 (COX-2) and elevation of its derivative prostaglandin E(2) (PGE(2)) are implicated in human esophageal squamous cell carcinoma. The expression of c-Myc, an oncogenic transcription factor, is also upregulated in ... Read more...

Navigating the leukocyte signaling maze guided by Ariadne's thread.

30 Oct 2009 Ariadne is the legendary Minoan goddess of the Labyrinth. The term 'Ariadne's thread' is used to describe the understanding of complex issues. Immunologists attending the 5th Leukocyte Signal Transduction Workshop discussed the Ariadne's thread ... Read more...

Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling.

19 Oct 2009 Prostaglandin E(2) (PGE(2)) mediates the masculinization of adult sex behavior in rats in response to the surge in serum testosterone at approximately birth. Measures of behavioral masculinization correlate with a twofold increase in spinophilin ... Read more...

Latest indexed articles for 'Dinoprostone'

These are the very latest articles for this heading:

• Prostaglandin E(2) promotes cell proliferation via protein kinase C/extracellular signal regulated kinase pathway-dependent induction of c-Myc expression in human esophageal squamous cell carcinoma cells. 29 Nov 2009
• Navigating the leukocyte signaling maze guided by Ariadne's thread. 30 Oct 2009
• Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. 19 Oct 2009
• Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. 12 Oct 2009
• Cerebrovascular cyclooxygenase-1 expression, regulation, and role in hypothalamic-pituitary-adrenal axis activation by inflammatory stimuli. 12 Oct 2009
• Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. 25 Sep 2009
• Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells. 20 Sep 2009
• Intrarenal dopamine attenuates deoxycorticosterone acetate/high salt-induced blood pressure elevation in part through activation of a medullary cyclooxygenase 2 pathway. 19 Sep 2009
• P2Y2 receptor transcription is increased by NF-kappa B and stimulates cyclooxygenase-2 expression and PGE2 released by intestinal epithelial cells. 2 Sep 2009
• E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II. 31 Aug 2009
• Effect of Sasa senanensis Rehder extract on NO and PGE2 production by activated mouse macrophage-like RAW264.7 cells. 30 Aug 2009
• Role of extracellular phospholipase B of Candida albicans as a virulent factor in experimental keratomycosis. 30 Aug 2009
• Dinoprostone compared with misoprostol for cervical ripening for induction of labor at term. 30 Aug 2009
• Aggravation by prostaglandin E2 of interleukin-6-dependent insulin resistance in hepatocytes. 30 Aug 2009
• Adipose-specific phospholipase as regulator of adiposity. 30 Aug 2009
• The effect of a peripheral block on inflammation-induced prostaglandin E2 and cyclooxygenase expression in rats. 30 Aug 2009
• Expression and activity of COX-1 and 2 and 5-LOX in joint tissues from dogs with naturally occurring coxofemoral joint osteoarthritis. 30 Aug 2009
• Cigarette smoke extract induces COX-2 expression via a PKCalpha/c-Src/EGFR, PDGFR/PI3K/Akt/NF-kappaB pathway and p300 in tracheal smooth muscle cells. 26 Aug 2009
• Prostaglandin E(2) primes the angiogenic switch via a synergic interaction with the fibroblast growth factor-2 pathway. 25 Aug 2009
• Prostaglandin EP2 and EP4 receptors modulate expression of the chemokine CCL2 (MCP-1) in response to LPS-induced renal glomerular inflammation. 25 Aug 2009

See a longer list of these articles.

Technical information about 'Dinoprostone'

Definition: The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.

Chemical name: Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, (5Z,11alpha,13E,15S)-

Registry Number: 363-24-6

Descriptor UI: D015232

Alternative terms: Dinoprostone; PGE2 alpha; alpha, PGE2; PGE2alpha; Prostaglandin E2 alpha; E2 alpha, Prostaglandin; alpha, Prostaglandin E2; Prostaglandin E2alpha; E2alpha, Prostaglandin; PGE2; Prostaglandin E2; E2, Prostaglandin; Prepidil Gel; Gel, Prepidil; Prostenon;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Oxytocics;

Tree Number: D10.251.355.255.100.637.250.200; D10.251.355.255.550.250.200; D23.469.050.175.725.780.200;

History Note: 89

Technical Notes: do not confuse with DINOPROST; /biosyn /physiol permitted