Diphtheria Toxin - Genetics
Research News and Information

Sunday, November 22, 2009

The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms.

Nov 2009 The diphtheria toxin T domain helps translocate the A chain of the toxin across membranes. To gain insight into translocation, the membrane topography of key residues in T domain attached to the A chain (AT protein) was compared to that in the ... Read more...

Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis.

29 Sep 2009 Pathogenic lymphocytes in the enteric wall of inflammatory bowel disease patients display various abnormalities, including reduced sensitivity to apoptosis. We evaluated a therapeutic approach to elimination of cytotoxic cells, using two IL-2 fusion ... Read more...

Kinetic intermediate reveals staggered pH-dependent transitions along the membrane insertion pathway of the diphtheria toxin T-domain.

16 Aug 2009 The pH-triggered membrane insertion pathway of the T-domain of diphtheria toxin was studied using site-selective fluorescence labeling with subsequent application of several spectroscopic techniques (e.g., fluorescence correlation spectroscopy, ... Read more...

Latest indexed articles for 'Diphtheria Toxin - Genetics'

These are the very latest articles for this heading:

• The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms. Nov 2009
• Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis. 29 Sep 2009
• Kinetic intermediate reveals staggered pH-dependent transitions along the membrane insertion pathway of the diphtheria toxin T-domain. 16 Aug 2009
• Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences. 4 Aug 2009
• A case of afebrile pneumonia caused by non-toxigenic Corynebacterium diphtheriae. 29 Jun 2009
• In mice lacking V2a interneurons, gait depends on speed of locomotion. 25 May 2009
• Generation of plant-derived recombinant DTP subunit vaccine. 15 Apr 2009
• Expression of a multi-epitope DPT fusion protein in transplastomic tobacco plants retains both antigenicity and immunogenicity of all three components of the functional oligomer. 19 Mar 2009
• Toxigenic Corynebacterium ulcerans isolated from the domestic dog for the first time in Japan. 27 Feb 2009
• Alteration of ocular surface mucins in MUC5AC-DTA transgenic mice. 14 Jan 2009
• [Polymorphism of tox and dtxR genes in circulating strains of Corynebacterium diphtheriae] 30 Dec 2008
• Use of the Rad51 promoter for targeted anti-cancer therapy. 21 Dec 2008
• Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells. Oct 2008
• Dominant inhibition of lens placode formation in mice. 24 Aug 2008
• A study of pore formation in lipid bilayers by modular nanotransporters containing the diphtheria toxin translocation domain. 29 Jun 2008
• Detection of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by a novel real-time PCR. 9 Jun 2008
• Behavior of the deeply inserted helices in diphtheria toxin T domain: helices 5, 8, and 9 interact strongly and promote pore formation, while helices 6/7 limit pore formation. 19 Mar 2008
• Endosomal proteolysis of diphtheria toxin without toxin translocation into the cytosol of rat liver in vivo. 27 Feb 2008
• A PCR for dtxR gene: application to diagnosis of non-toxigenic and toxigenic Corynebacterium diphtheriae. 12 Feb 2008
• Regulated expression of adenoviral vectors-based gene therapies: therapeutic expression of toxins and immune-modulators. 30 Dec 2007

See a longer list of these articles.

Technical information about 'Diphtheria Toxin'

Definition: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.

Registry Number: 0

Descriptor UI: D004167

Alternative terms: Diphtheria Toxin; Toxin, Corynebacterium Diphtheriae; Corynebacterium Diphtheriae Toxin;

Related Mesh Headings: Diphtheria Toxoid;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Poisons;

Tree Number: D08.811.913.400.725.115.220; D23.946.123.305;

Technical Notes: /antag permitted but consider also DIPHTHERIA ANTITOXIN