Diphtheria Toxin - Pharmacology
Research News and Information

Sunday, November 22, 2009

Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis.

29 Sep 2009 Pathogenic lymphocytes in the enteric wall of inflammatory bowel disease patients display various abnormalities, including reduced sensitivity to apoptosis. We evaluated a therapeutic approach to elimination of cytotoxic cells, using two IL-2 fusion ... Read more...

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia.

30 Aug 2009 Tumor-induced immune suppression can permit tumor cells to escape host immune resistance. To elucidate host factors contributing to the poor response of adoptively transferred tumor-reactive cytotoxic T lymphocytes (CTLs), we used a systemic model ... Read more...

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli.

16 May 2009 Behavioral responses to painful stimuli require peripheral sensory neurons called nociceptors. Electrophysiological studies show that most C-fiber nociceptors are polymodal (i.e., respond to multiple noxious stimulus modalities, such as mechanical ... Read more...

Latest indexed articles for 'Diphtheria Toxin - Pharmacology'

These are the very latest articles for this heading:

• Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis. 29 Sep 2009
• Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. 30 Aug 2009
• Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. 16 May 2009
• Whatever happened to immunotoxins? Research, and hope, are still alive. 26 Apr 2009
• Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. 5 Apr 2009
• D2R striatopallidal neurons inhibit both locomotor and drug reward processes. 6 Mar 2009
• Maturation of mouse NK cells is a 4-stage developmental program. 18 Feb 2009
• [Regulatory T-cells and their role in antitumor immune response] 30 Dec 2008
• Reoxygenation of hypoxic glioblastoma multiforme cells potentiates the killing effect of an interleukin-13-based cytotoxin. 30 Dec 2008
• Acute myeloid leukemia-targeted toxin activates both apoptotic and necroptotic death mechanisms. 9 Dec 2008
• Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice. 4 Dec 2008
• Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation. 13 Nov 2008
• Enhanced interleukin-2 diphtheria toxin conjugate-induced growth suppression in retinoic acid-treated hypoxic hepatocellular carcinoma cells. 2 Nov 2008
• Role of dendritic cells in enhancement of herpes simplex virus type 1 latency and reactivation in vaccinated mice. 27 Oct 2008
• Genetically engineering transferrin to improve its in vitro ability to deliver cytotoxins. 19 Oct 2008
• Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. 8 Oct 2008
• A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. 29 Sep 2008
• Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development. 31 Aug 2008
• Optimizing denileukin diftitox (Ontak) therapy. 30 Jul 2008
• Langerhans cell dogma: another round of rejections. 30 Jul 2008

See a longer list of these articles.

Technical information about 'Diphtheria Toxin'

Definition: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.

Registry Number: 0

Descriptor UI: D004167

Alternative terms: Diphtheria Toxin; Toxin, Corynebacterium Diphtheriae; Corynebacterium Diphtheriae Toxin;

Related Mesh Headings: Diphtheria Toxoid;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Poisons;

Tree Number: D08.811.913.400.725.115.220; D23.946.123.305;

Technical Notes: /antag permitted but consider also DIPHTHERIA ANTITOXIN