Diphtheria Toxin
Research News and Information

Sunday, November 22, 2009

The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms.

Nov 2009 The diphtheria toxin T domain helps translocate the A chain of the toxin across membranes. To gain insight into translocation, the membrane topography of key residues in T domain attached to the A chain (AT protein) was compared to that in the ... Read more...

Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis.

29 Sep 2009 Pathogenic lymphocytes in the enteric wall of inflammatory bowel disease patients display various abnormalities, including reduced sensitivity to apoptosis. We evaluated a therapeutic approach to elimination of cytotoxic cells, using two IL-2 fusion ... Read more...

Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia.

30 Aug 2009 Tumor-induced immune suppression can permit tumor cells to escape host immune resistance. To elucidate host factors contributing to the poor response of adoptively transferred tumor-reactive cytotoxic T lymphocytes (CTLs), we used a systemic model ... Read more...

Latest indexed articles for 'Diphtheria Toxin'

These are the very latest articles for this heading:

• The membrane topography of the diphtheria toxin T domain linked to the a chain reveals a transient transmembrane hairpin and potential translocation mechanisms. Nov 2009
• Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis. 29 Sep 2009
• Depletion of endogenous tumor-associated regulatory T cells improves the efficacy of adoptive cytotoxic T-cell immunotherapy in murine acute myeloid leukemia. 30 Aug 2009
• Kinetic intermediate reveals staggered pH-dependent transitions along the membrane insertion pathway of the diphtheria toxin T-domain. 16 Aug 2009
• Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences. 4 Aug 2009
• Deciphering membrane insertion of the diphtheria toxin T domain by specular neutron reflectometry and solid-state NMR spectroscopy. 29 Jun 2009
• A case of afebrile pneumonia caused by non-toxigenic Corynebacterium diphtheriae. 29 Jun 2009
• Seroprevalence and placental transportation of maternal antibodies specific for Neisseria meningitidis serogroup C, Haemophilus influenzae type B, diphtheria, tetanus, and pertussis. 29 Jun 2009
• A transgenic mouse model of inducible macrophage depletion: effects of diphtheria toxin-driven lysozyme M-specific cell lineage ablation on wound inflammatory, angiogenic, and contractive processes. 13 Jun 2009
• Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. 9 Jun 2009
• Preclinical efficacy of the bioreductive alkylating agent RH1 against paediatric tumours. 31 May 2009
• Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. 27 May 2009
• In mice lacking V2a interneurons, gait depends on speed of locomotion. 25 May 2009
• Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. 16 May 2009
• Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network. 12 May 2009
• Fatal hyperacute graft-versus-host disease following denileukin diftitox treatment for recurrent t cell lymphoma after allogeneic stem cell transplantation. 11 May 2009
• Side chain resonances in static oriented proton-decoupled 15N solid-state NMR spectra of membrane proteins. 11 May 2009
• Diphtheria: a zoonotic disease in France? 3 May 2009
• Whatever happened to immunotoxins? Research, and hope, are still alive. 26 Apr 2009
• Impaired fear response in mice lacking GIT1. 17 Apr 2009

See a longer list of these articles.

Technical information about 'Diphtheria Toxin'

Definition: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.

Registry Number: 0

Descriptor UI: D004167

Alternative terms: Diphtheria Toxin; Toxin, Corynebacterium Diphtheriae; Corynebacterium Diphtheriae Toxin;

Related Mesh Headings: Diphtheria Toxoid;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Poisons;

Tree Number: D08.811.913.400.725.115.220; D23.946.123.305;

Technical Notes: /antag permitted but consider also DIPHTHERIA ANTITOXIN