Diterpenes, Abietane - Pharmacology
Research News and Information

Sunday, November 22, 2009

Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.

30 Jul 2009 The new aromatic diterpenes 7beta-O-benzylrosmanol (3), 7beta-O-benzyl-11,12-di-O-methylrosmanol (4), and 7alpha-thiophenylcarnosic acid (5) have been obtained by partial synthesis from carnosol (1), an abundant natural diterpene present in Salvia ... Read more...

Mechanisms underlying the vasorelaxant action of the pimarane ent-8(14),15-pimaradien-3beta-ol in the isolated rat aorta.

16 Jun 2009 Pimarane-type diterpenes were described to exert antispasmodic and relaxant activities. Based on this observation we hypothesized that the diterpene ent-8(14),15-pimaradien-3beta-ol (PA-3beta-ol) induced vascular relaxation. With this purpose, the ... Read more...

[Synthesis of dihydroquinopymaric acid conjugates with amino acids]

29 Apr 2009 Synthesis of dihydroquinopymaric acid amides and their 2beta-succinyl and 2beta-phthalyl derivatives containing residues of amino acids was carried out for the first time. Antiviral properties of the compounds synthesized were ... Read more...

Latest indexed articles for 'Diterpenes, Abietane - Pharmacology'

These are the very latest articles for this heading:

• Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone. 30 Jul 2009
• Mechanisms underlying the vasorelaxant action of the pimarane ent-8(14),15-pimaradien-3beta-ol in the isolated rat aorta. 16 Jun 2009
• [Synthesis of dihydroquinopymaric acid conjugates with amino acids] 29 Apr 2009
• c-Jun N-terminal kinase 2 (JNK2) antagonizes the signaling of differentiation by JNK1 in human myeloid leukemia cells resistant to vitamin D. 29 Mar 2009
• Carnosic acid and carnosol inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism. 12 Mar 2009
• ent-Abietane and ent-kaurane diterpenoids from the roots of Suregada glomerulata. 21 Feb 2009
• Synthesis and biological evaluation of abietic acid derivatives. 22 Jan 2009
• Carnosic acid reduces cytokine-induced adhesion molecules expression and monocyte adhesion to endothelial cells. 11 Jan 2009
• Pimarane-type diterpenes: antimicrobial activity against oral pathogens. 2 Jan 2009
• Carnosol delays chemotherapy-induced DNA fragmentation and morphological changes associated with apoptosis in leukemic cells. 30 Dec 2008
• Reversion of P-glycoprotein-mediated multidrug resistance in human leukemic cell line by carnosic acid. 29 Dec 2008
• Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation. 28 Dec 2008
• Antiparasitic, nematicidal and antifouling constituents from Juniperus berries. 29 Nov 2008
• Trypanocidal activity of abietane diterpenoids from the roots of Craniolaria annua. 30 Oct 2008
• Synthesis, structure analysis and cytotoxicity studies of novel unsymmetrically n,n'-substituted ureas from dehydroabietic Acid. 30 Oct 2008
• Novel oxime and oxime ether derivatives of 12,14-dichlorodehydroabietic acid: design, synthesis, and BK channel-opening activity. 20 Oct 2008
• Trypanocidal activity of pimarane diterpenes from Viguiera arenaria (Asteraceae). 29 Sep 2008
• Gerardianin A, a new abietane diterpenoid from Isodon lophanthoides var. gerardianus. 30 Aug 2008
• A novel opener of large-conductance Ca2+ -activated K+ (BK) channel reduces ischemic injury in rat cardiac myocytes by activating mitochondrial K(Ca) channel. 28 Aug 2008
• Novel BK channel openers containing dehydroabietic acid skeleton: structure-activity relationship for peripheral substituents on ring C. 26 Aug 2008

See a longer list of these articles.

Technical information about 'Diterpenes, Abietane'

Definition: A group of DITERPENES cyclized into 3-ring PHENANTHRENES.

Registry Number: 0

Descriptor UI: D045784

Alternative terms: Diterpenes, Abietane; Abietane Diterpenes; Abietanes; Diterpenes, Pimarane; Pimarane Diterpenes; Pimaranes;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.426.559.847.723.590; D02.455.849.291.206; D04.615.723.590;

History Note: 2004