Diynes - Pharmacology
Research News and Information

Monday, November 23, 2009

Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress.

11 Jun 2009 In the present study, we isolated falcarindiol from Notopterygium incisum and investigated the effect of falcarindiol on the expression of antioxidant enzymes (AOEs), such as catalase, and phase 2 drug-metabolizing enzymes (DMEs), such as ... Read more...

Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2.

16 May 2009 Panaxydol, a polyacetylene compound isolated from Panax ginseng, exerts anti-proliferative effects against malignant cells. No previous study, however, has been reported on its effects on hepatocellular carcinoma cells. Here, we investigated the ... Read more...

Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol.

27 Feb 2009 Panaxydol isolated from the lipophilic fractions of Tienchi ginseng (Panax notoginseng) induces growth inhibition and differentiation of rat C6 glioma cells. The underlying molecular mechanisms are not completely understood. In the present study, we ... Read more...

Latest indexed articles for 'Diynes - Pharmacology'

These are the very latest articles for this heading:

• Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress. 11 Jun 2009
• Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2. 16 May 2009
• Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol. 27 Feb 2009
• Cyclic AMP-dependent regulation of differentiation of rat C6 glioma cells by panaxydol. 24 Nov 2008
• Indoleacetic acid falcarindiol ester induces granulocytic differentiation of the human leukemia cell line HL-60. 22 Nov 2008
• Panaxydol treatment enhances the biological properties of Schwann cells in vitro. 29 Aug 2008
• Effect of panaxydol on hypoxia-induced cell death and expression and secretion of neurotrophic factors (NTFs) in hypoxic primary cultured Schwann cells. 2 May 2008
• Antimycobacterial polyacetylenes from Levisticum officinale. 29 Apr 2008
• Growth inhibition and induction of differentiation by panaxydol in rat C6 glioma cells. 30 Jan 2008
• Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity. 12 Jan 2008
• Antiproliferative effect of panaxynol on RASMCs via inhibition of ERK1/2 and CREB. 6 Dec 2007
• Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils. 12 Nov 2007
• The polyacetylene falcarindiol with COX-1 activity isolated from Aegopodium podagraria L. 4 May 2007
• A small molecule Smac mimic potentiates TRAIL-mediated cell death of ovarian cancer cells. 7 Feb 2007
• Biphasic effect of falcarinol on caco-2 cell proliferation, DNA damage, and apoptosis. 5 Feb 2007
• Induction of apoptosis in rat C6 glioma cells by panaxydol. 12 Jan 2007

See a longer list of these articles.

Technical information about 'Diynes'

Definition: Compounds with two triple bonds. Some of them are CYTOTOXINS.

Registry Number: 0

Descriptor UI: D053280

Alternative terms: Diynes;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.326.397.662.500;

History Note: 2007