Diynes
Research News and Information

Sunday, November 22, 2009

Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress.

11 Jun 2009 In the present study, we isolated falcarindiol from Notopterygium incisum and investigated the effect of falcarindiol on the expression of antioxidant enzymes (AOEs), such as catalase, and phase 2 drug-metabolizing enzymes (DMEs), such as ... Read more...

Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2.

16 May 2009 Panaxydol, a polyacetylene compound isolated from Panax ginseng, exerts anti-proliferative effects against malignant cells. No previous study, however, has been reported on its effects on hepatocellular carcinoma cells. Here, we investigated the ... Read more...

Poisoning due to water hemlock.

30 Mar 2009 INTRODUCTION: Water hemlock, which encompasses a range of species divided across two genera (Cicuta and Oenanthe), are regarded as being among the most poisonous plants both in North America and in the United Kingdom. Despite their toxicity, the ... Read more...

Latest indexed articles for 'Diynes'

These are the very latest articles for this heading:

• Heterogeneously catalyzed efficient alkyne-alkyne homocoupling by supported copper hydroxide on titanium oxide. Aug 2009
• Induction of antioxidant and phase 2 drug-metabolizing enzymes by falcarindiol isolated from Notopterygium incisum extract, which activates the Nrf2/ARE pathway, leads to cytoprotection against oxidative and electrophilic stress. 11 Jun 2009
• Panaxydol inhibits the proliferation and induces the differentiation of human hepatocarcinoma cell line HepG2. 16 May 2009
• Poisoning due to water hemlock. 30 Mar 2009
• Phosphatidylinositol 3-kinase activity is required for the induction of differentiation in C6 glioma cells by panaxydol. 27 Feb 2009
• Nickel-catalyzed oxidative coupling reactions of two different terminal alkynes using O(2) as the oxidant at room temperature: facile syntheses of unsymmetric 1,3-diynes. 3 Feb 2009
• Effects of cytochrome P450 arachidonic acid epoxygenases on the proliferation of tumor cells. 3 Jan 2009
• From conjugated tertiary skipped diynes to chain-functionalized tetrasubstituted pyrroles. 30 Dec 2008
• Highly efficient access to bi- and tricyclic ketals through gold-catalyzed tandem reactions of 4-acyl-1,6-diynes. 30 Dec 2008
• Biomass and content of ginsenosides and polyacetylenes in American ginseng roots can be increased without affecting the profile of bioactive compounds. 14 Dec 2008
• Cyclic AMP-dependent regulation of differentiation of rat C6 glioma cells by panaxydol. 24 Nov 2008
• Indoleacetic acid falcarindiol ester induces granulocytic differentiation of the human leukemia cell line HL-60. 22 Nov 2008
• Panaxydol treatment enhances the biological properties of Schwann cells in vitro. 29 Aug 2008
• Synthesis of 2-cyclohexenone derivatives via gold(I)-catalyzed hydrative cyclization of 1,6-diynes. 26 Aug 2008
• Effect of panaxydol on hypoxia-induced cell death and expression and secretion of neurotrophic factors (NTFs) in hypoxic primary cultured Schwann cells. 2 May 2008
• Antimycobacterial polyacetylenes from Levisticum officinale. 29 Apr 2008
• Substituent effects in the preparation of naphthacenes by the coupling reaction of diyne-derived zirconacyclopentadienes with tetraiodobenzene. 30 Jan 2008
• Growth inhibition and induction of differentiation by panaxydol in rat C6 glioma cells. 30 Jan 2008
• Panaxydol and panaxynol protect cultured cortical neurons against Abeta25-35-induced toxicity. 12 Jan 2008
• Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. 29 Dec 2007

See a longer list of these articles.

Technical information about 'Diynes'

Definition: Compounds with two triple bonds. Some of them are CYTOTOXINS.

Registry Number: 0

Descriptor UI: D053280

Alternative terms: Diynes;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.455.326.397.662.500;

History Note: 2007