Dizocilpine Maleate
Research News and Information

Monday, November 23, 2009

The time course of dopamine transmission in the ventral tegmental area.

19 Oct 2009 Synaptic transmission mediated by G-protein coupled receptors (GPCR) is not generally thought to be point-to-point. To determine the extent over which dopamine signals in the midbrain, the present study examined the concentration and time course of ... Read more...

Factors governing single-trial contextual fear conditioning in the weanling rat.

29 Sep 2009 Although contextual fear conditioning emerges later in development than explicit-cue fear conditioning, little is known about the stimulus parameters and biological substrates required at early ages. The authors adapted methods for investigating ... Read more...

The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice.

14 Sep 2009 Granulocyte-colony stimulating factor (G-CSF) is a hematopoietic growth factor that controls proliferation and differentiation of neural stem cells. Although recent studies have begun to explore G-CSF-related mechanisms of action in various disease ... Read more...

Latest indexed articles for 'Dizocilpine Maleate'

These are the very latest articles for this heading:

• The time course of dopamine transmission in the ventral tegmental area. 19 Oct 2009
• Factors governing single-trial contextual fear conditioning in the weanling rat. 29 Sep 2009
• The role of granulocyte-colony stimulating factor (G-CSF) in the healthy brain: a characterization of G-CSF-deficient mice. 14 Sep 2009
• CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity. 5 Sep 2009
• Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist. 25 Aug 2009
• Older and stronger object memories are selectively destabilized by reactivation in the presence of new information. 25 Aug 2009
• 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. 16 Aug 2009
• Development of a behavior model of pain induced by experimental tooth movement in rats. 30 Jul 2009
• NMDA receptors mediate an early up-regulation of brain-derived neurotrophic factor expression in substantia nigra in a rat model of presymptomatic Parkinson's disease. 30 Jul 2009
• Neurochemical mechanisms of consolidation of associative aversive learning to food in the common snail. 20 Jul 2009
• Neither in vivo MRI nor behavioural assessment indicate therapeutic efficacy for a novel 5HT(1A) agonist in rat models of ischaemic stroke. 14 Jul 2009
• MK801-induced activated caspase-3 exhibits selective co-localization with GAD67. 7 Jul 2009
• PDGF-mediated protection of SH-SY5Y cells against Tat toxin involves regulation of extracellular glutamate and intracellular calcium. 30 Jun 2009
• Podocyte glutamatergic signaling contributes to the function of the glomerular filtration barrier. 30 Jun 2009
• [Effects of NMDA and metabotropic glutamate receptors antagonists in working memory task in rats] 29 Jun 2009
• Principal cell spiking, postsynaptic excitation, and oxygen consumption in the rat cerebellar cortex. 29 Jun 2009
• An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons. 29 Jun 2009
• In vivo [(123)I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats. 29 Jun 2009
• Neonatal exposure to MK801 promotes prepulse-induced delay in startle response time in adult rats. 28 Jun 2009
• Acute and chronic fentanyl administration causes hyperalgesia independently of opioid receptor activity in mice. 22 Jun 2009

See a longer list of these articles.

Technical information about 'Dizocilpine Maleate'

Definition: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.

Chemical name: 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1)

Registry Number: 77086-22-7

Descriptor UI: D016291

Alternative terms: Dizocilpine Maleate; MK-801; MK 801; MK801; Dizocilpine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Neuroprotective Agents; Excitatory Amino Acid Antagonists;

Tree Number: D02.455.426.559.847.181.384.380; D04.615.181.384.380;

History Note: 91

Technical Notes: DF: note short X