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DNA - Chemistry
Research News and Information
Definition of 'DNA'A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). |
Saturday, November 21, 2009
Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin.
15 Nov 2009 
Enhanced expression of cyclooxygenase-2 (COX-2) is associated with development of several cancers. The product of COX-2, prostaglandin H(2) (PGH(2)), can undergo spontaneous rearrangement and nonenzymatic ring cleavage to form the highly reactive ... Read more...
8 Nov 2009 The study of interactions of protein with DNA is important for gaining a fundamental understanding of how numerous biological processes occur, including recombination, transcription, repair, etc. In this study, we use the EcoRII restriction enzyme, ... Read more...
Nov 2009 The helicase-primase complex from herpes simplex virus-1 contains three subunits, UL5, UL52, and UL8. We generated each of the potential two-subunit complexes, UL5-UL52, UL5-UL8, and UL52-UL8, and used a series of kinetic and photo-cross-linking ... Read more...
Latest indexed articles for 'DNA - Chemistry'
These are the very latest articles for this heading:
- Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin. 15 Nov 2009
- Single-molecule dynamics of the DNA-EcoRII protein complexes revealed with high-speed atomic force microscopy. 8 Nov 2009
- Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation. Nov 2009
- The cis-(5R,6S)-thymine glycol lesion occupies the wobble position when mismatched with deoxyguanosine in DNA. 18 Oct 2009
- Effect of GC base pairs on charge transfer through DNA hairpins: the importance of electrostatic interactions. 12 Oct 2009
- Comprehensive mapping of long-range interactions reveals folding principles of the human genome. 7 Oct 2009
- Heretical DNA sequences?
7 Oct 2009 - Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. 6 Oct 2009
- Technical note: removal of metal ion inhibition encountered during DNA extraction and amplification of copper-preserved archaeological bone using size exclusion chromatography. 29 Sep 2009
- DNA-catalyzed hydrolysis of DNA phosphodiesters. 29 Sep 2009
- Lymphoid enhancer binding factor 1 regulates transcription through gene looping. 23 Sep 2009
- Chemistry. Emergent or just complex? 23 Sep 2009
- Portability of the GN(R)A hairpin loop motif between RNA and DNA. 20 Sep 2009
- Conformational transition of giant DNA in a confined space surrounded by a phospholipid membrane. 14 Sep 2009
- Super-resolution imaging of DNA labelled with intercalating dyes. 12 Sep 2009
- Checkpoint signaling from a single DNA interstrand crosslink. 9 Sep 2009
- Single-molecule analysis reveals differential effect of ssDNA-binding proteins on DNA translocation by XPD helicase. 9 Sep 2009
- XPD helicase speeds through a molecular traffic jam. 9 Sep 2009
- Excited states of DNA base pairs using long-range corrected time-dependent density functional theory. 8 Sep 2009
- Recognition of single mismatched DNA using MutS-immobilized carbon nanotube field effect transistor devices. 8 Sep 2009
See a longer list of these articles.
Technical information about 'DNA'
Definition: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Chemical name: Deoxyribonucleic acids
Registry Number: 9007-49-2
Descriptor UI: D004247
Alternative terms: DNA; Deoxyribonucleic Acid; DNA, B-Form; B-Form DNA; DNA, B Form; B-DNA; DNA, Double-Stranded; DNA, Double Stranded; Double-Stranded DNA; ds-DNA;
Related Mesh Headings: Genetic Code; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Repetitive Sequences, Nucleic Acid; DNA Primers;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D13.444.308;
Technical Notes: GEN: prefer specifics; /biosyn permitted but consider also DNA REPLICATION; structural DNA models = DNA (IM) + MOLECULAR MODELS (IM)