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DNA - Metabolism
Research News and Information
Definition of 'DNA'A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). |
Sunday, November 22, 2009
8 Nov 2009 
The study of interactions of protein with DNA is important for gaining a fundamental understanding of how numerous biological processes occur, including recombination, transcription, repair, etc. In this study, we use the EcoRII restriction enzyme, ... Read more...
Characterization and structure of the manganese-responsive transcriptional regulator ScaR.
Nov 2009 The streptococcal coaggregation regulator (ScaR) of Streptococcus gordonii is a manganese-dependent transcriptional regulator. When intracellular manganese concentrations become elevated, ScaR represses transcription of the scaCBA operon, which ... Read more...
Nov 2009 The helicase-primase complex from herpes simplex virus-1 contains three subunits, UL5, UL52, and UL8. We generated each of the potential two-subunit complexes, UL5-UL52, UL5-UL8, and UL52-UL8, and used a series of kinetic and photo-cross-linking ... Read more...
Latest indexed articles for 'DNA - Metabolism'
These are the very latest articles for this heading:
- Single-molecule dynamics of the DNA-EcoRII protein complexes revealed with high-speed atomic force microscopy. 8 Nov 2009
- Characterization and structure of the manganese-responsive transcriptional regulator ScaR. Nov 2009
- Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation. Nov 2009
- E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin. 30 Oct 2009
- Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. 6 Oct 2009
- Structural biology: Tracing Argonaute binding.
6 Oct 2009 - Relative contributions of chromatin and kinetochores to mitotic spindle assembly. 3 Oct 2009
- Regulation of vascularization by hypoxia-inducible factor 1. 29 Sep 2009
- Solution structure of the DNA binding domain of AraC protein. 29 Sep 2009
- Incidence of fragile X syndrome by newborn screening for methylated FMR1 DNA. 29 Sep 2009
- DNA-catalyzed hydrolysis of DNA phosphodiesters. 29 Sep 2009
- Metal ion interactions in the DNA cleavage/ligation active site of human topoisomerase IIalpha. 27 Sep 2009
- Lymphoid enhancer binding factor 1 regulates transcription through gene looping. 23 Sep 2009
- The C-terminal domain is sufficient for endonuclease activity of Neisseria gonorrhoeae MutL. 23 Sep 2009
- Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification. 22 Sep 2009
- N-hydroxybenzimidazole inhibitors of the transcription factor LcrF in Yersinia: novel antivirulence agents. 22 Sep 2009
- Extracting the causality of correlated motions from molecular dynamics simulations. 14 Sep 2009
- Conformational transition of giant DNA in a confined space surrounded by a phospholipid membrane. 14 Sep 2009
- Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity. 14 Sep 2009
- Identification of direct transcriptional target genes of ExoS/ChvI two-component signaling in Sinorhizobium meliloti. 9 Sep 2009
See a longer list of these articles.
Technical information about 'DNA'
Definition: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Chemical name: Deoxyribonucleic acids
Registry Number: 9007-49-2
Descriptor UI: D004247
Alternative terms: DNA; Deoxyribonucleic Acid; DNA, B-Form; B-Form DNA; DNA, B Form; B-DNA; DNA, Double-Stranded; DNA, Double Stranded; Double-Stranded DNA; ds-DNA;
Related Mesh Headings: Genetic Code; Nucleic Acid Denaturation; Nucleic Acid Hybridization; Repetitive Sequences, Nucleic Acid; DNA Primers;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D13.444.308;
Technical Notes: GEN: prefer specifics; /biosyn permitted but consider also DNA REPLICATION; structural DNA models = DNA (IM) + MOLECULAR MODELS (IM)