Dopamine Antagonists - Pharmacology
Research News and Information

Saturday, November 21, 2009

Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat.

29 Sep 2009 Male rats display a conditioned preference to ejaculate with a female bearing an odor paired previously with copulation to ejaculation. The present study examined the role of endogenous opioid and dopamine systems in this preference. Male rats ... Read more...

Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine.

29 Sep 2009 Treatment with topiramate may improve negative symptoms in schizophrenia when added to typical antipsychotic drugs (APDs) but not to clozapine. Both dopaminergic and glutamatergic transmissions in the medial prefrontal cortex (mPFC) are facilitated ... Read more...

Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration.

29 Sep 2009 Exposure to cocaine causes many neuroadaptations including alterations in several neurotransmitter receptors and transporters. This study investigated potential mechanisms of cocaine-induced receptor and transporter regulation by measuring levels of ... Read more...

Latest indexed articles for 'Dopamine Antagonists - Pharmacology'

These are the very latest articles for this heading:

• Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. 29 Sep 2009
• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• Regulation of dynamin 2 and G protein-coupled receptor kinase 2 in rat nucleus accumbens during acute and repeated cocaine administration. 29 Sep 2009
• Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors. 14 Sep 2009
• NCS-1 in the dentate gyrus promotes exploration, synaptic plasticity, and rapid acquisition of spatial memory. 8 Sep 2009
• In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. 20 Aug 2009
• Dopamine controls persistence of long-term memory storage. 19 Aug 2009
• Presynaptic action of neurotensin on dopamine release through inhibition of D(2) receptor function. 12 Aug 2009
• Roles of octopaminergic and dopaminergic neurons in appetitive and aversive memory recall in an insect. 2 Aug 2009
• Dopaminergic modulation of olfactory bulb processing affects odor discrimination learning in rats. 30 Jul 2009
• Long-term ventilatory adaptation and ventilatory response to hypoxia in plateau pika (Ochotona curzoniae): role of nNOS and dopamine. 27 Jul 2009
• Albumin endocytosis via megalin in astrocytes is caveola- and Dab-1 dependent and is required for the synthesis of the neurotrophic factor oleic acid. 23 Jul 2009
• [Effect of sulpiride on immobility reflex and pinch-induced catalepsy in CBA/Lac male mice with various social status] 29 Jun 2009
• Predictability of intranasal pharmacokinetics in man using pre-clinical pharmacokinetic data with a dopamine 3 receptor agonist, PF-219061. 29 Jun 2009
• Righting elicited by novel or familiar auditory or vestibular stimulation in the haloperidol-treated rat: rat posturography as a model to study anticipatory motor control. 22 Jun 2009
• Social support and striatal dopaminergic activities: is there a connection? 19 Jun 2009
• Investigation of a dopamine receptor in Schistosoma mansoni: functional studies and immunolocalization. 19 Jun 2009
• [(3)H]-YM-09151-2 binding sites in human brain postmortem. 16 Jun 2009
• Serotonergic and dopaminergic modulation of gambling behavior as assessed using a novel rat gambling task. 15 Jun 2009
• Effects of dopamine D1 and D2 receptor antagonists on laryngeal neurophysiology in the rat. 15 Jun 2009

See a longer list of these articles.

Technical information about 'Dopamine Antagonists'

Definition: Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

Registry Number: 0

Descriptor UI: D018492

Alternative terms: Dopamine Antagonists; Antagonists, Dopamine Receptor; Receptor Antagonists, Dopamine; Dopaminergic Antagonists; Dopamine Blockers; Blockers, Dopamine; Dopamine Receptor Antagonists; Antagonists, Dopamine; Antagonists, Dopaminergic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.150.175; D27.505.696.577.150.175;

History Note: 95

Technical Notes: DF: DOPAMINE ANTAG