Dopamine Plasma Membrane Transport Proteins - Deficiency
Research News and Information

Monday, November 23, 2009

Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling.

22 Jun 2009 Neural phase signaling has gained attention as a putative coding mechanism through which the brain binds the activity of neurons across distributed brain areas to generate thoughts, percepts, and behaviors. Neural phase signaling has been shown to ... Read more...

Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice.

26 Jan 2009 There has been much interest in the relative importance of dopamine and serotonin transporters in the abuse-related-effects of cocaine. We tested the hypotheses that mice lacking the dopamine transporter (DAT(-/-)), the serotonin transporter ... Read more...

Cocaine does not produce reward in absence of dopamine transporter inhibition.

5 Jan 2009 We have previously reported that knockin mice with a cocaine-insensitive dopamine transporter (DAT-CI mice) do not experience cocaine reward, as measured by conditioned place preference. This conclusion has come under scrutiny because some ... Read more...

Latest indexed articles for 'Dopamine Plasma Membrane Transport Proteins - Deficiency'

These are the very latest articles for this heading:

• Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. 22 Jun 2009
• Clinical reasoning: Blurred vision and dancing feet: restless legs syndrome presenting in mitochondrial disease. 3 May 2009
• Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. 26 Jan 2009
• Cocaine does not produce reward in absence of dopamine transporter inhibition. 5 Jan 2009
• Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. 4 Nov 2008
• Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. 4 Nov 2008
• Reduced tumor growth in a mouse model of schizophrenia, lacking the dopamine transporter. 30 Jul 2008
• Trace amine associated receptor 1 and movement control. 25 Jun 2008
• Reprint of "Neurobiology of animal models of attention-deficit hyperactivity disorder". 28 Nov 2007
• Increased dopamine D2High receptors in knockouts of the dopamine transporter and the vesicular monoamine transporter may contribute to spontaneous hyperactivity and dopamine supersensitivity. 29 Jun 2007
• Cocaine reward and locomotion stimulation in mice with reduced dopamine transporter expression. 19 Jun 2007
• Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice. 21 May 2007
• Nicotine improves cognitive deficits of dopamine transporter knockout mice without long-term tolerance. 19 Mar 2007
• Functional alterations of nicotinic neurotransmission in dopamine transporter knock-out mice. 22 Feb 2007
• RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. 23 Oct 2006
• Dopaminergic control of sleep-wake states. 9 Oct 2006
• Reduced expression and capacity of the striatal high-affinity choline transporter in hyperdopaminergic mice. May 2006
• Norepinephrine transporter blockade can normalize the prepulse inhibition deficits found in dopamine transporter knockout mice. 9 Jan 2006
• Mice with chronically elevated dopamine exhibit enhanced motivation, but not learning, for a food reward. 21 Nov 2005
• Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons. 2 Oct 2005

See a longer list of these articles.

Technical information about 'Dopamine Plasma Membrane Transport Proteins'

Definition: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.

Registry Number: 0

Descriptor UI: D050483

Alternative terms: Dopamine Plasma Membrane Transport Proteins; DAT Dopamine Transporter Proteins; Dopamine Carriers; Carriers, Dopamine; Neurotransmitter Transporters, Dopamine-Specific; Dopamine-Specific Neurotransmitter Transporters; Neurotransmitter Transporters, Dopamine Specific; Transporters, Dopamine-Specific Neurotransmitter; Dopamine Transporter; Transporter, Dopamine; Dopamine Transporter Proteins; Transporter Proteins, Dopamine; Neurotransmitter Transport Proteins, Dopamine-Specific; Neurotransmitter Transport Proteins, Dopamine Specific; DAT Dopamine Transporter; Dopamine Transporter, DAT; Transporter, DAT Dopamine; Dopamine Plasma Membrane Transporter Proteins; Dopamine Uptake Complex;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.530.450.625.124; D12.776.157.530.562.374.500.500; D12.776.543.585.450.625.124; D12.776.543.585.562.374.500.500;

History Note: 2006(1987)