Dopamine Plasma Membrane Transport Proteins
Research News and Information

Monday, November 23, 2009

Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia.

30 Oct 2009 CONTEXT: The dopamine transporter plays a key role in the regulation of central dopaminergic transmission, which modulates cognitive processing. Disrupted dopamine function and impaired executive processing are robust features of schizophrenia. ... Read more...

Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters.

6 Oct 2009 Stereodefined trisubstituted cyclopropanes bearing naphthyloxy, thiophenyl, and (N-methylamino)methyl groups were synthesized in enantiopure form employing asymmetric cyclopropanation of (E)- and (Z)-allylic alcohols as the key step. In vitro assays ... Read more...

In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand.

29 Sep 2009 This study evaluated the in vitro and in vivo characteristics of a new dopamine transporter (DAT) radioligand, [(18)F]fluoroethyl(FE)PE2I, by autoradiography from postmortem human brain and by positron emission tomography (PET) in three cynomolgus ... Read more...

Latest indexed articles for 'Dopamine Plasma Membrane Transport Proteins'

These are the very latest articles for this heading:

• Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia. 30 Oct 2009
• Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters. 6 Oct 2009
• In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand. 29 Sep 2009
• Dopaminergic haplotype as a predictor of spatial inattention in children with attention-deficit/hyperactivity disorder. 29 Sep 2009
• A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. 29 Sep 2009
• 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors. 22 Sep 2009
• Influences of polymorphic variants of DRD2 and SLC6A3 genes, and their combinations on smoking in Polish population. 15 Sep 2009
• The 18F-FDG PET cingulate island sign and comparison to 123I-beta-CIT SPECT for diagnosis of dementia with Lewy bodies. 14 Sep 2009
• Evaluating dopamine reward pathway in ADHD: clinical implications. 7 Sep 2009
• Cardiac repolarization and striatal dopamine transporter function are interrelated. 30 Aug 2009
• Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats. 25 Aug 2009
• [Role of dopamine transporter gene (DAT1) polymorphisms in personality traits variation] 30 Jul 2009
• Disruption of the dopamine transporter-dopamine D2 receptor interaction in schizophrenia. 30 Jul 2009
• No association between lithium full responders and the DRD1, DRD2, DRD3, DAT1, 5-HTTLPR and HTR2A genes in a Sardinian sample. 29 Jul 2009
• Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. 28 Jul 2009
• Epistasis between the DAT 3' UTR VNTR and the COMT Val158Met SNP on cortical function in healthy subjects and patients with schizophrenia. 26 Jul 2009
• Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. 21 Jul 2009
• Rab 11 regulates constitutive dopamine transporter trafficking and function in N2A neuroblastoma cells. 20 Jul 2009
• Genetic alteration in the dopamine transporter differentially affects male and female nigrostriatal transporter systems. 13 Jul 2009
• Lack of cocaine self-administration in mice expressing a cocaine-insensitive dopamine transporter. 12 Jul 2009

See a longer list of these articles.

Technical information about 'Dopamine Plasma Membrane Transport Proteins'

Definition: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.

Registry Number: 0

Descriptor UI: D050483

Alternative terms: Dopamine Plasma Membrane Transport Proteins; DAT Dopamine Transporter Proteins; Dopamine Carriers; Carriers, Dopamine; Neurotransmitter Transporters, Dopamine-Specific; Dopamine-Specific Neurotransmitter Transporters; Neurotransmitter Transporters, Dopamine Specific; Transporters, Dopamine-Specific Neurotransmitter; Dopamine Transporter; Transporter, Dopamine; Dopamine Transporter Proteins; Transporter Proteins, Dopamine; Neurotransmitter Transport Proteins, Dopamine-Specific; Neurotransmitter Transport Proteins, Dopamine Specific; DAT Dopamine Transporter; Dopamine Transporter, DAT; Transporter, DAT Dopamine; Dopamine Plasma Membrane Transporter Proteins; Dopamine Uptake Complex;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.530.450.625.124; D12.776.157.530.562.374.500.500; D12.776.543.585.450.625.124; D12.776.543.585.562.374.500.500;

History Note: 2006(1987)