Dopamine Uptake Inhibitors - Pharmacology
Research News and Information

Saturday, November 21, 2009

A neurocomputational model for cocaine addiction.

29 Sep 2009 Based on the dopamine hypotheses of cocaine addiction and the assumption of decrement of brain reward system sensitivity after long-term drug exposure, we propose a computational model for cocaine addiction. Utilizing average reward temporal ... Read more...

In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand.

29 Sep 2009 This study evaluated the in vitro and in vivo characteristics of a new dopamine transporter (DAT) radioligand, [(18)F]fluoroethyl(FE)PE2I, by autoradiography from postmortem human brain and by positron emission tomography (PET) in three cynomolgus ... Read more...

c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues.

29 Sep 2009 The capability of cocaine cues to generate craving in cocaine-dependent humans, even after extended abstinence, is modeled in rats using cue reinstatement of extinguished cocaine-seeking behavior. We investigated neural activity associated with ... Read more...

Latest indexed articles for 'Dopamine Uptake Inhibitors - Pharmacology'

These are the very latest articles for this heading:

• A neurocomputational model for cocaine addiction. 29 Sep 2009
• In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand. 29 Sep 2009
• c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues. 29 Sep 2009
• [Neuroenhancement: doping for the brain] 27 Sep 2009
• Dopaminergic response to graded dopamine concentration elicited by four amphetamine doses. 30 Aug 2009
• Attenuated behavioural responses to acute and chronic cocaine in GASP-1-deficient mice. 25 Aug 2009
• In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. 20 Aug 2009
• A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. 30 Jul 2009
• Inactivating the activated: identifying functions of specific neural networks. 30 Jul 2009
• Dopaminergic activity in depressed smokers: a positron emission tomography study. 30 Jul 2009
• Acquisition of and withdrawal from cocaine self-administration regulates 5-HT mRNA expression in rat striatum. 28 Jul 2009
• Fluoxetine (Prozac) binding to serotonin transporter is modulated by chloride and conformational changes. 27 Jul 2009
• Orexin/hypocretin signaling at the orexin 1 receptor regulates cue-elicited cocaine-seeking. 26 Jul 2009
• Targeted disruption of cocaine-activated nucleus accumbens neurons prevents context-specific sensitization. 18 Jul 2009
• In vivo cocaine experience generates silent synapses. 14 Jul 2009
• Antidepressant treatment facilitates dopamine release and drug seeking behavior in a genetic animal model of depression. 13 Jul 2009
• Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. 11 Jul 2009
• Disagreements with implications: diverging discourses on the ethics of non-medical use of methylphenidate for performance enhancement. 4 Jul 2009
• Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. 22 Jun 2009
• Cocaine modulates locomotion behavior in C. elegans. 15 Jun 2009

See a longer list of these articles.

Technical information about 'Dopamine Uptake Inhibitors'

Definition: Drugs that block the transport of DOPAMINE into axon terminals or into storage vesicles within terminals. Most of the ADRENERGIC UPTAKE INHIBITORS also inhibit dopamine uptake.

Registry Number: 0

Descriptor UI: D018765

Alternative terms: Dopamine Uptake Inhibitors; Reuptake Inhibitors, Dopamine; Inhibitors, Dopamine Uptake; Uptake Inhibitors, Dopamine; Inhibitors, Dopamine Reuptake; Dopamine Reuptake Inhibitors;

Allowable Qualifiers: history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists; administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics;

Tree Number: D27.505.519.625.150.800; D27.505.519.625.600.220; D27.505.696.577.150.800; D27.505.696.577.600.220;

History Note: 95

Technical Notes: GEN or unspecified; prefer specifics; DF: DOPAMINE UPTAKE INHIB