Dopamine
Research News and Information

Saturday, November 21, 2009

GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions.

Nov 2009 GPR37, also known as the parkin-associated endothelin-like receptor (Pael-R), is an orphan G-protein-coupled receptor (GPCR) that exhibits poor plasma membrane expression when expressed in most cell types. We sought to find ways to enhance GPR37 ... Read more...

Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain?

30 Oct 2009 Corticosteroid receptor modulation of mesoaccumbens dopamine neurotransmission is believed to be a key neurobiological mechanism mediating the effects of stress in addiction. Importantly, nucleus accumbens (NAc) subregions (core and shell) are ... Read more...

Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors.

30 Oct 2009 The dopamine D4 receptor (D4R) is predominantly expressed in the prefrontal cortex, a brain area that integrates motor, rewarding, and cognitive information. Because participation of D4Rs in executive learning is largely unknown, we challenged D4R ... Read more...

Latest indexed articles for 'Dopamine'

These are the very latest articles for this heading:

• GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions. Nov 2009
• Dopexamine and survival: areas of consistency. 30 Oct 2009
• Differential corticosteroid receptor regulation of mesoaccumbens dopamine efflux during the peak and nadir of the circadian rhythm: a molecular equilibrium in the midbrain? 30 Oct 2009
• Reward-seeking and discrimination deficits displayed by hypodopaminergic mice are prevented in mice lacking dopamine D4 receptors. 30 Oct 2009
• Endocannabinoid modulation of amphetamine sensitization is disrupted in a rodent model of lesion-induced dopamine dysregulation. 30 Oct 2009
• In vivo measurement of somatodendritic release of dopamine in the ventral tegmental area. 30 Oct 2009
• Altered effect of dopamine transporter 3'UTR VNTR genotype on prefrontal and striatal function in schizophrenia. 30 Oct 2009
• The time course of dopamine transmission in the ventral tegmental area. 19 Oct 2009
• SnapShot: pathogenesis of Parkinson's disease. 14 Oct 2009
• A neural circuit mechanism integrating motivational state with memory expression in Drosophila. 14 Oct 2009
• Writing memories with light-addressable reinforcement circuitry. 14 Oct 2009
• Neuroscience. Fetal cells again? 14 Oct 2009
• Comparison of the spatial distribution of seven types of neuroendocrine neurons in the rat paraventricular nucleus: toward a global 3D model. 8 Oct 2009
• Autocrine activation of neuronal NMDA receptors by aspartate mediates dopamine- and cAMP-induced CREB-dependent gene transcription. 5 Oct 2009
• Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. 5 Oct 2009
• Neurons of the dopaminergic/calcitonin gene-related peptide A11 cell group modulate neuronal firing in the trigeminocervical complex: an electrophysiological and immunohistochemical study. 5 Oct 2009
• Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway. 5 Oct 2009
• Naloxone, but not flupenthixol, disrupts the development of conditioned ejaculatory preference in the male rat. 29 Sep 2009
• Critical review of ropinirole and pramipexole - putative dopamine D(3)-receptor selective agonists - for the treatment of RLS. 29 Sep 2009
• A neurocomputational model for cocaine addiction. 29 Sep 2009

See a longer list of these articles.

Technical information about 'Dopamine'

Definition: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.

Chemical name: 1,2-Benzenediol, 4-(2-aminoethyl)-

Registry Number: 51-61-6

Descriptor UI: D004298

Alternative terms: Dopamine; Hydroxytyramine; 3,4-Dihydroxyphenethylamine; 3,4 Dihydroxyphenethylamine; 4-(2-Aminoethyl)-1,2-benzenediol; Intropin; Dopamine Hydrochloride; Hydrochloride, Dopamine;

Related Mesh Headings: Levodopa; Receptors, Dopamine; Dopamine Agents;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Pharmacological Action: Sympathomimetics; Dopamine Agents; Cardiotonic Agents;

Tree Number: D02.092.211.215.311.342; D02.092.311.342;